35994-86-6

Upstream product

• 108-98-5 thiophenol 
• 501-65-5 diphenyl acetylene 
• 882-33-7 diphenyldisulfane 
• 24466-59-9 (E)-(1,2-diphenylvinyl)(phenyl)sulfane 
• 931-59-9 benzenesulfenyl chloride 
• 128787-44-0 (E)-(N)-(4-nitrophenyl)-S-phenyl-S-<2-(phenylthio)-1,2-diphenylvinyl>sulphimide 
• 64168-52-1 4'-nitrobenzenesulfenanilide 
• 75-05-8 acetonitrile 

Downstream Products

• 84796-80-5 (E)-1,2-Bis(phenylsulphonyl)stilbene 

Relevant academic research and scientific papers

Bis-vinyl selenides obtained via iron(iii) catalyzed addition of PhSeSePh to alkynes: Synthesis and antinociceptive activity

In the present study the synthesis and antinociceptive activity of bis-vinyl selenides, prepared via FeCl3 promoted reaction addition of diorganyl dichalcogenides to alkynes, is described. The pharmacological results demonstrated that bis-vinyl selenides 3a, 3d, 3h and 3t elicited antinociceptive effect in the mouse formalin test. The antinociceptive effects of bis-vinyl selenides are not sensitive to electronic effects of the substituents on the aromatic ring directly bonded to the selenium atom. Bis-vinyl selenides 3h and 3t were the most promising molecules for pharmacological purposes since these bis-vinyl selenides were effective in both phases of the formalin test and against edema. A single dose of bis-vinyl selenides 3a, 3d, 3h and 3t did not cause acute toxicity in mice.

Addition of ArSSAr to carbon-carbon multiple bonds using electrochemistry

ArS(ArSSAr)+ (arylbis(arylthio)sulfonium ions), which were generated and accumulated by the electrochemical oxidation of diaryl disulfides (ArSSAr) in CH2Cl2 at -78 °C, reacted with alkenes to give the corresponding diaryl

Boron Trifluoride-promoted Reaction of 4'-Nitrobenzenesulphenanilide with Alkynes. Formal Addition of Benzenesulphenyl Fluoride to Carbon-Carbon Triple Bonds

The BF3-promoted reaction of 4'-nitrobenzenesulphenanilide with simple alkyl- and aryl-alkynes at 80 deg C in the presence of tetrabutylammonium tetrafluoroborate provides a one-pot synthetic route to β-fluorovinyl sulphides via a formal regioselective and trans-stereospecific addition of benzenesulphenyl fluoride towards carbon-carbon triple bonds.

ELECTROPHILIC ADDITION OF 4'-NITROBENZENESULPHENANILIDE TO ALKYNES, EFFECTS OF ARYL AND ALKYL SUBSTITUENTS AT RING CARBONS OF INTERMEDIATE THIIRENIUM IONS

The BF3-promoted addition of 4'-nitrobenzenesulphenanilide, NBSA, to a number of aryl- and alkyl-acetylenes has been investigated in dichloromethane, p-xylene and/or benzene.Diphenylacetylene, 1a, 1-phenylbutyne, 1b, and 1-phenylpropyne, 1c, generally lead to 1,2-bis(phenylthio)alkenes 4a-c, and N-(4-nitrophenyl)-S-phenyl-S-(2-phenylthiovinyl)sulphimides, 6a-c, in fair to good yields with trans stereospecificity.Phenylacetylene, 1d, similarly gives the corresponding bis(phenylthio)adduct 4d and sulphimide 6d in dichloromethane, but in the aromatic solvents these products are essentially suppressed in favour of 1-aryl-1-phenyl-2-(phenylthio)ethylenes 7d.On the other hand, alkyl- and, particularly, dialkyl-substituted acetylenes preferentially afford β-fluorovinyl sulphides, 5, with trans stereospecifity.These findings are interpreted in terms of a different reactivity towards nucleophilic attack of the intermediate aryl- and alkyl-trihirenium ions which would result from electrophilic sulphenylation of the corresponding alkynes.Steric effects of the substituents are believed to play a major role in determining the different reactivity observed.

Synthesis of (E)- and (Z)-1,2-Bis(phenylsulphonyl)stilbenes

(E)- and (Z)-1,2-bis(phenylsulphonyl)stilbenes (12 and 9) have been synthesized starting from (E)- and (Z)-1-phenylthiostilbenes (1 and 3).The geometrical configurations of these compounds have been established through stereospecific synthesis.