360-34-9

Usage

InChI:InChI=1/C6H9F3O/c1-2-3-4-5(10)6(7,8)9/h2-4H2,1H3

Upstream product

• 109-72-8 n-butyllithium 
• 60-29-7 diethyl ether 
• 76-05-1 trifluoroacetic acid 
• 383-63-1 ethyl trifluoroacetate, 
• 1009-14-9 phenyl butyl ketone 
• 495-40-9 propiophenone 
• 709-24-0 1-(4-fluorophenyl)-1-pentanone 
• 7295-44-5 4'-bromovalerophenone 
• 42916-70-1 1-(2-chlorophenyl)-pentan-1-one 
• 1671-77-8 n-butyl p-tolyl ketone 
• 1671-76-7 p-Methoxyvalerophenon 
• 131379-19-6 Ethyl 4-(1-oxopentyl)benzoate 
• 2876-60-0 1-(naphthalen-1-yl)pentan-1-one 
• 3194-17-0 1-furan-2-yl-pentan-1-one 

Downstream Products

• 110230-42-7 2-chloro-1-phenyl-4-(trifluoromethyl)-4-octanol 
• 110230-40-5 1-phenyl-4-(trifluoromethyl)-1-octen-4-ol 
• 110230-41-6 2-butyl-5-phenyl-2-(trifluoromethyl)tetrahydrofuran 
• 127700-37-2 C₂₁H₃₃F₃N₂O₂S 
• 134166-52-2 l-3-<1-(trifluoromethyl)-1-hydroxypentyl>cyclohexene 
• 141779-30-8 1-butyl-1-(trifluoroacetyl)cyclohexane 
• 1357382-97-8 C₁₃H₁₆F₃NO 
• 127700-47-4 C₂₄H₂₄F₃N₂P 
• 138824-22-3 4-hexadecyloxybiphenyl-4'-carboxylic acid-4''-(3-trifluoromethylheptyl)phenyl ester 
• 138824-21-2 4-dodecyloxybiphenyl-4'-carboxylic acid-4''-(3-trifluoromethylheptyl)phenyl ester 
• 138824-20-1 4-decyloxybiphenyl-4'-carboxylic acid-4''(3-trifluoromethylheptyl)phenyl ester 
• 138824-19-8 4'-Octyloxy-biphenyl-4-carboxylic acid 4-(3-trifluoromethyl-heptyl)-phenyl ester 
• 138824-31-4 4-(5-Heptyl-pyrimidin-2-yl)-benzoic acid 4-(3-trifluoromethyl-heptyl)-phenyl ester 
• 138824-18-7 4-hexyloxybiphenyl-4'-carboxylic acid-4''-(3-trifluoromethylheptyl)phenyl ester 

Relevant academic research and scientific papers

Highly selective trifluoroacetic ester/ketone metathesis: An efficient approach to trifluoromethyl ketones and esters

A highly selective and atom efficient 'trifluoroacetic ester/ketone metathesis' has been sincerely witnessed. Enolizable alkyl (at least two non-hydrogen atoms) aryl ketones were found to react readily with ethyl trifluoroacetate under the promotion of NaH to afford trifluoroacetic ester/ketone exchange products, trifluoromethyl ketones (TFMKs), and aromatic acid esters, which were quite different from the general Claisen condensation products, 1,3-diketones. The outcome of the reaction between ketone and ethyl trifluoroacetate is strongly related to the structures of substrates, the steric congestion caused by alkyl group is in favor of the C-C bond cleavage. DFT investigation further disclosed that the metathesis reaction was a kinetically favored pathway. Using only a slight excess of cheap trifluoromethylation reagent, simple operation and mild conditions make it a practical method for preparation of TFMKs on large scale, as well as a new choice of converting aryl alkyl ketones to aromatic acid esters.

Synthesis of trifluoromethyl ketones via tandem Claisen condensation and retro-Claisen C-C bond-cleavage reaction

A highly efficient, operationally simple approach to trifluoromethyl ketones has been developed that builds on the use of a tandem process involving Claisen condensation and retro-Claisen C-C bond cleavage reaction. Enolizable alkyl phenyl ketones were found to react readily with ethyl trifuoroacetate under the promotion of NaH to afford trifluoroacetic ester/ketone exchange products, trifluoromethyl ketones, which were quite different from the general Claisen condensation products, β-diketones. This procedure uses readily available starting materials and can be extended to the preparation of perfluoroalkyl ketones in excellent yield.