360-80-5Relevant academic research and scientific papers
Energy barrier determination of enantiomerization of chiral 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide type compounds by enantioselective stopped-flow HPLC
Cannazza, Giuseppe,Braghiroli, Daniela,Iuliani, Piera,Parenti, Carlo
, p. 3158 - 3162 (2006)
The synthesis and enantioseparation of chiral 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide derivatives are reported herein. A HPLC stopped-flow procedure was applied to the determination of rate constants and free energy barriers of enantiomerization of the compounds synthesized in the presence of achiral stationary phase. The individual enantiomers of the studied compounds were isolated in parallel by preparative HPLC on a Chiraspher NT column. Rate constants and free energy barriers of enantiomerization were determined in the mobile phase. The results were used to determine the influence of the chiral stationary phase on the enantiomerization process.
Preparation method of benzothiadiazine-1, 1-dioxide compound
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Paragraph 0110-0114, (2021/07/17)
The invention relates to a synthesis method of a benzothiadiazine-1, 1-dioxide compound, and develops a novel solvent-free synthesis method of the benzothiadiazine-1, 1-dioxide compound. No solvent is added in the reaction process, and even part of the product can be obtained through separation without post-treatment. Therefore, the separation and purification process of the product is easy to implement, the reaction time is shortened, the yield of the product is increased, the yield can reach 73%-98%, the purity can reach 96%-99%, the use of toxic solvents is reduced to the greatest extent, and the problems of resource waste, environmental pollution and the like caused by the solvents are fundamentally solved. The method thoroughly eliminates the heavy metal pollution problem in the product from the source, is suitable for preparation of active pharmaceutical ingredients (API), biological agents and the like, and meets the requirements of green chemistry concept.
Metal-free oxidative cyclization of 2-amino-benzamides, 2-aminobenzenesulfonamide or 2-(aminomethyl)anilines with primary alcohols for the synthesis of quinazolinones and their analogues
Sun, Jinwei,Tao, Tao,Xu, Dan,Cao, Hui,Kong, Qinggang,Wang, Xinyu,Liu, Yun,Zhao, Jianglin,Wang, Yi,Pan, Yi
, p. 2099 - 2102 (2018/05/04)
A general metal-free oxidative cyclization process has been developed for the synthesis of quinazolinones, benzothiadiazines and quinazolines. By this protocol, a range of substituted 2-aminobenzamides, 2-aminobenzenesulfonamide and 2-(aminomethyl)anilines react with various alcohols, leading to the desired annulated products smoothly. This protocol features many advantages as broad substrate scope, mild reaction conditions, low environmental pollution, high atom-economy and good to excellent yields.
Highly Enantioselective Synthesis of Cyclic Aminals with a Cyclopentadiene-Based Chiral Carboxylic Acid
Sui, Yuebo,Cui, Peng,Liu, Sensheng,Zhou, Yanmei,Du, Peng,Zhou, Haifeng
supporting information, p. 215 - 218 (2018/01/26)
A highly enantioselective aminalization of 2-aminobenzenesulfonamides and aldehydes catalyzed by a novel cyclopentadiene-based chiral carboxylic acid has been realized. The cost-effective and readily synthesized cyclopentadiene-based chiral carboxylic aci
Iron-catalyzed oxidative synthesis of N-heterocycles from primary alcohols
Zhao, Dan,Zhou, Yu-Ren,Shen, Qi,Li, Jian-Xin
, p. 6486 - 6489 (2014/02/14)
An iron-catalyzed one-pot one-step oxidative system has been successfully developed in the conversion of primary alcohols into nitrogen-containing heterocycles, such as quinazolinone, quinazoline and 3,4-dihydro-2H-1,2,4- benzothiadiazine 1,1-dioxide derivatives.
