3600-61-1

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 99-93-4 4-Hydroxyacetophenone 
• 457629-77-5 4,4'-bis(tetrahydropyran-2-yloxy)chalcone 
• 2373-89-9 4,4'-dimethoxychalcone 
• 123-11-5 4-methoxy-benzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 109555-07-9 4,4'-diacetoxychalcone 

Downstream Products

• 112163-64-1 4,4'-dinonyloxychalcone 
• 112163-65-2 (E)-1,3-Bis-(4-decyloxy-phenyl)-propenone 
• 72666-15-0 1,3-bis(4-hydroxyphenyl) propanone 
• 1222313-22-5 4-(4'-hydroxyphenyl)-2-(4-hydroxyphenyl)-2,3-dihydro-1,5-benzoxazepine 
• 1222313-17-8 4-(4'-hydroxyphenyl)-2-(4-hydroxyphenyl)-2,3-dihydro-1,5-benzothiazepine 
• 1428324-88-2 1-(3,5-bis(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethan-1-one 

Relevant academic research and scientific papers

Method for efficiently synthesizing 1, 3-bis (4-hydroxyphenyl)-2-propylene-1-ketone

The invention discloses a method for efficiently synthesizing 1, 3-bis (4-hydroxyphenyl)-2-propene-1-ketone, and belongs to the field of organic chemical synthesis. According to the method, a Claisen-Schmidt reaction is carried out, p-hydroxybenzaldehyde

Antibacterial and anti-inflammatory activity of valproic acid-pyrazole conjugates as a potential agent against periodontitis

Periodontitis is a serious global concern. Therefore, in the present study, we intend to synthesize novel valproic-acid pyrazole conjugates as a novel agent against periodontitis. The molecules were developed in a facile synthetic route and obtained in ex

Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia

Based on hit-likeness and chemical diversity, a number of chalcones and chalcone-mimetic compounds were selected as putative Notch inhibitors. The evaluation of the antiproliferative effect combined with the inhibition of Notch1 expression in KOPTK1 cell line identified compound 18, featuring a tetrahydronaphthalene-based scaffold, as a new promising Notch-blocking agent.

Crosslinking Monomers With at Least One Sulfur Atom

The invention relates to a cross-linking monomer with at least one sulfur atom, representable by a structure of formula (I) wherein the symbols have the following meaning: L1 is a linear, branched or cyclic, saturated or unsaturated, aliphatic

BENZOXAZINES WITH PHOTO-CURABLE LINKAGES, THERMOSETS THEREOF, AND PREPARATION OF THE SAME

The subject invention provides benzoxazines with photo-curable linkages, thermosets thereof, and preparation methods of the same. The compounds of the subject invention can be used in manufacture of many kinds of cross-linking polymer material, and the obtained material is improved in terms of many properties, especially high thermal properties. Moreover, the preparation method of the subject invention can precisely synthesize the targeted products by simply steps.

Triaryl Pyrazole Toll-Like Receptor Signaling Inhibitors: Structure–Activity Relationships Governing Pan- and Selective Signaling Inhibitors

The immune system uses members of the toll-like receptor (TLR) family to recognize a variety of pathogen- and host-derived molecules in order to initiate immune responses. Although TLR-mediated, pro-inflammatory immune responses are essential for host defense, prolonged and exaggerated activation can result in inflammation pathology that manifests in a variety of diseases. Therefore, small-molecule inhibitors of the TLR signaling pathway might have promise as anti-inflammatory drugs. We previously identified a class of triaryl pyrazole compounds that inhibit TLR signaling by modulation of the protein–protein interactions essential to the pathway. We have now systematically examined the structural features essential for inhibition of this pathway, revealing characteristics of compounds that inhibited all TLRs tested (pan-TLR signaling inhibitors) as well as compounds that selectively inhibited certain TLRs. These findings reveal interesting classes of compounds that could be optimized for particular inflammatory diseases governed by different TLRs.

Photo-sensitive benzoxazine II: Chalcone-containing benzoxazine and its photo and thermal-cured thermoset

A chalcone-containing benzoxazine (BHP-a) was synthesized from a chalcone-containing bisphenol: 1,3-bis(4-hydroxyphenyl) propanone (BHP), aniline and paraformaldehyde in a co-solvent of xylene/1-butanol (2/1, V/V). The structure of BHP-a was successfully

Synthesis and biological activity of 2,4-di-p-phenolyl-6-2-furanyl-pyridine as a potent topoisomerase II poison

Dihydroxylated 2,4-diphenyl-6-aryl pyridine derivatives were simply achieved using Claisen-Schmidt condensation reaction and modified Kr?hnke pyridine synthetic method. Total forty-five compounds were designed and synthesized which contain hydroxyl groups

The mesomorphic properties of chalcone dimer derivatives

A homologous series of symmetrical dimers viz bis (4-n-alkoxy benzoyloxy) -phenyl β-benzoyl-ethylenes was synthesized and studied with a view to understanding the relation between molecular structure and the mesomorphic behavior. Twelve members of the dimeric series were synthesized, and the methoxy to butyloxy homologues are not liquid crystals, but the pentyloxy to hexadecyloxy are liquid crystals. The pentyl to heptyl dimers are only nematogenic, but the higher homologues show smectogenic mesomorphism prior to nematogenic mesophase formation. The phase diagram of phase transition curves behaves in a normal manner except for the smectic to nematic transition curve which behaves in an unexpected manner. The smectic and nematic thermal stabilities are 103°C and 131.7°C, respectively. The smectogenic and nematogenic phase lengths vary between 17.4°C to 28.3°C and 2.1°C to 29.9°C, respectively. The liquid crystal properties of presently investigated novel chalcone dimers are compared with known monomeric chalcones.

Synthesis and biological activity of 2,4-di- p -phenolyl-6- 2 -furanyl-pyridine as a potent topoisomerase II poison

Dihydroxylated 2,4-diphenyl-6-aryl pyridine derivatives were simply achieved using Claisen-Schmidt condensation reaction and modified Kr?hnke pyridine synthetic method. Total forty-five compounds were designed and synthesized which contain hydroxyl groups