825619-04-3

Basic information

• Product Name: 1H-Pyrazole-3-carboxylic acid, 4-[(2,6-dichlorobenzoyl)aMino]-
• Synonyms: 1H-Pyrazole-3-carboxylic acid, 4-[(2,6-dichlorobenzoyl)aMino]-;4-(2,6-Dichlorobenzamido)-1H-pyrazole-3-carboxylic acid
• CAS NO: 825619-04-3
• Molecular Formula: C₁₁H₇Cl₂N₃O₃
• Molecular Weight: 300.09758
• Mol File: 825619-04-3.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 482.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.702±0.06 g/cm3(Predicted)
• PKA: 3.12±0.36(Predicted)
• CAS DataBase Reference: 1H-Pyrazole-3-carboxylic acid, 4-[(2,6-dichlorobenzoyl)aMino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-3-carboxylic acid, 4-[(2,6-dichlorobenzoyl)aMino]-(825619-04-3)
• EPA Substance Registry System: 1H-Pyrazole-3-carboxylic acid, 4-[(2,6-dichlorobenzoyl)aMino]-(825619-04-3)

Safety Data

• Hazardous Substances Data: 825619-04-3(Hazardous Substances Data)

Usage

Derivative of pyrazole

yes

Contains a carboxylic acid

yes

Contains a dichlorobenzoyl group

yes

Commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals

yes

Potential applications in medicinal chemistry and drug development

yes

Structural properties and functional groups

contribute to its potential applications

Exhibits antimicrobial and antineoplastic activities

yes

Promising candidate for further research and development in pharmaceutical sciences

yes

Upstream product

• 4659-45-4 2,6-Dichlorobenzoyl chloride 
• 825619-05-4 methyl 4-(2,6-dichlorobenzamido)-1H-pyrazole-3-carboxylate 
• 360056-45-7 methyl 4-amino-1H-pyrazole-3-carboxylate 
• 55904-61-5 4-amino-1H-pyrazole-3-carboxylic acid ethyl ester 

Downstream Products

• 844443-90-9 tert-butyl 4-(4-(2,6-dichlorobenzamido)-1H-pyrazole-3-carboxamido)piperidine-1-carboxylate 
• 1002114-29-5 4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid 
• 902156-99-4 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid (1-methanesulphonyl-piperidin-4-yl)-amide 

Relevant articles and documents

Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity

Cyclin-dependent kinase 14 (CDK14) and other TAIRE family kinases (CDKs 15–18) are proteins that lack functional annotation but are frequent off-targets of clinical kinase inhibitors. In this study we develop and characterize FMF-04-159-2, a tool compound

TAIRE FAMILY KINASE INHIBITORS AND USES THEREOF

Provided herein are compounds of Formula (I′) or (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are met

COMBINATIONS OF PYRAZOLE DERIVATIVES FOR THE INHIBITION OF CDKS AND GSK'S

A combination comprising (a) a compound of formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein X is R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C═O, NR9