360059-20-7

Usage

Uses

Used in Pharmaceutical Industry:
(S)-3-Amino-3-(4-methoxyphenyl)propionic acid ethyl ester is used as a building block for the synthesis of various drugs and bioactive molecules, due to its unique structure and potential biological activity.
Used in Drug Synthesis:
In the field of drug synthesis, (S)-3-Amino-3-(4-methoxyphenyl)propionic acid ethyl ester is utilized as a key component in the development of new pharmaceuticals, potentially leading to the creation of novel treatments for various medical conditions.
Used in Research and Development:
This chemical compound is also employed in research and development settings to study its properties, interactions, and potential applications, furthering the understanding of its role in the pharmaceutical industry and the development of new therapeutic agents.

Upstream product

• 2881-83-6 ethyl 4-methoxybenzoylacetate 
• 90788-35-5 ethyl 3-amino-4-(4-methoxyphenyl)-2-butenoate 

Downstream Products

• 99075-49-7 3-amino-3-(4-methoxy-phenyl)-propionaldehyde 
• 109593-20-6 <3-Amino-3-(4-methoxy-phenyl)-propionyl>-N-methyl-anilid 

Relevant academic research and scientific papers

Chiral Lewis Base-Catalyzed, Enantioselective Reduction of Unprotected β-Enamino Esters with Trichlorosilane

Catalytic asymmetric reduction of N-unsubstituted β-enamino esters represents a major challenge for asymmetric catalysis. In this paper, the first organocatalytic system that could be used for the asymmetric hydrosilylation of N-unsubstituted β-enamino esters has been developed. Using N-tert-butylsulfinyl-L-proline-derived amides and L-pipecolinic acid-derived formamides as catalyst, a broad range of β-aryl- and β-alkyl-substituted free β-amino esters could be prepared with high yields and enantioselectivities. The practicality was illustrated by the gram-scale asymmetric synthesis of ethyl (R)-3-amino-3-phenylpropanoate and isopropyl (S)-3-amino-4-(2,3,5-trifluorophenyl)butanoate. The resulting product can be smoothly transformed to the FDA approved medicines dapoxetine and sitagliptin in a short synthetic route.

3-AMINO-3-ARYLPROPIONIC ACID n-ALKYL ESTERS, PROCESS FOR PRODUCTION THEREOF, AND PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE 3-AMINO-3-ARYLPROPIONIC ACIDS AND ESTERS OF THE ANTIPODES THERETO

The present invention is to provide an n-alkyl 3-amino-3-arylpropionate represented by the formula (I): wherein Ar1 represents an aryl group which may have a substituent(s), provided that a phenyl group and 4-methoxyphenyl group are excluded, R1 represents an n-propyl group or an n-butyl group, and a process for preparing the same, and its optically active compound and an optically active (S or R)-3-amino-3-arylpropionic acid represented by the formula (III-a): wherein Ar represents an aryl group which may have a substituent(s), and * represents an asymmetric carbon, and a process for preparing an optically active n-alkyl (R or S)-3-amino-3-arylpropionate represented by the formula (IV-a): wherein Ar and R1 have the same meanings as defined above, * represents an asymmetric carbon, provided that it has a reverse absolute configuration to the compound of the formula (III-a).