360068-90-2

Upstream product

• 7459-73-6 (4-Vinylphenyl)magnesium chloride 
• 77581-28-3 (S)-proline-N-ethyl carbamate methyl ester 
• 1073-67-2 4-vinylbenzyl chloride 
• 18120-63-3 (4-vinylphenyl)magnesium bromide 
• 5700-74-3 (S)-N-(ethoxycarbonyl)proline 
• 2039-82-9 1-bromo-4-ethenyl-benzene 

Downstream Products

• 1262281-20-8 (S)-α,α-bis(4-vinylphenyl)prolinol trimethylsilyl ether 
• 157020-06-9 (S)-(-)-α,α-di(4-vinylphenyl)-2-pyrrolidinemethanol 

Relevant academic research and scientific papers

Organocatalytic Enantioselective Continuous-Flow Cyclopropanation

A set of six solid-supported diarylprolinol catalysts (varying on the anchoring strategy and the type of polymeric support) has been prepared and applied to the enantioselective cyclopropanation reaction. The selected candidate allows implementation of a long flow experiment (48 h) and generates a library of 12 cyclopropanes by sequential flow experiments. The mildness and utility of the method have enabled a telescoped process in which the outstream is directly used in a Wittig flow reaction.

A heterogeneous layered bifunctional catalyst for the integration of aerobic oxidation and asymmetric C-C bond formation

The design and synthesis of a heterogeneous bifunctional chiral catalyst for the sequential aerobic oxidation-asymmetric Michael reactions between primary allylic alcohols and dibenzyl malonate are described. Interestingly, we found that layering bimetallic nanoparticles over the organocatalyst, within the chiral composite material, is crucial for catalytic activity.

Superparamagnetic nanoparticle-Supported (S)-diphenyl- prolinol trimethylsilyl ether as a recyclable catalyst for asymmetric Michael addition in water

A new superparamagnetic nanoparticle-supported (S)-diphenylprolinol trimethylsilyl ether (Jorgensen-Hayashi catalyst) was synthesized and applied for the asymmetric Michael addition of aldehydes to nitroalkenes in water, which gives products in moderate t

Immobilization of chiral ligands on polymer fibers by electron beam induced grafting and applications in enantioselective catalysis

(Equation presented) Styrenic TADDOL and L-prolinol-derived monomers were immobilized on polyethylene fibers by electron beam induced preirradiation grafting using styrene as comonomer. The polymer-supported chiral ligands were utilized as catalysts in th