36025-18-0Relevant academic research and scientific papers
Building Congested Ketone: Substituted Hantzsch Ester and Nitrile as Alkylation Reagents in Photoredox Catalysis
Chen, Wenxin,Liu, Zheng,Tian, Jiaqi,Li, Jin,Ma, Jing,Cheng, Xu,Li, Guigen
, p. 12312 - 12315 (2016)
For the first time, 4-alkyl Hantzsch esters were used to construct molecules with all-carbon quaternary centers by visible light-induced photoredox catalysis via transfer alkylation. Up to a 1500 h-1 turnover frequency was achieved in this reaction. Reactions of 4-alkyl Hantzsch nitriles as tertiary radical donors joined two contiguous all-carbon quaternary centers intermolecularly, and this chemistry was used to synthesize a common precursor of a class of hydroxysteroid dehydrogenase inhibitors.
Intermolecular C-H Quaternary Alkylation of Aniline Derivatives Induced by Visible-Light Photoredox Catalysis
Cheng, Jie,Deng, Xia,Wang, Guoqiang,Li, Ying,Cheng, Xu,Li, Guigen
supporting information, p. 4538 - 4541 (2016/09/28)
The intermolecular direct C-H alkylation of aniline derivatives with α-bromo ketones to build a quaternary carbon center was reported with a visible-light catalysis procedure. The reaction covers a variety of functional groups with good to excellent yield
