36037-36-2

Usage

InChI:InChI=1/C9H9ClO2/c1-6-3-7(2)5-8(4-6)12-9(10)11/h3-5H,1-2H3

Upstream product

• 75-44-5 phosgene 
• 108-68-9 3,5-Dimethylphenol 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 141036-99-9 Carbonic acid cyclohex-2-enyl ester 3,5-dimethyl-phenyl ester 
• 22134-19-6 α,α'-dichloro-3,5-xylenyl N-methylcarbamate 
• 22134-31-2 α,α'-Dichlor-3,5-xylenyl N-isopropylcarbamat 
• 22228-94-0 α,α,α'-Trichlor-3,5-xylenyl N-methylcarbamat 
• 53122-99-9 α,α,α,α'-Tetrachloro-3,5-xylyl-N-methylcarbamat 
• 36155-21-2 α-thiocyano-3,5-xylenyl N-methylcarbamate 
• 22134-18-5 α-chloro-3,5-xylenyl N-methylcarbamate 
• 22134-30-1 α,α'-Dichloro-3,4-xylyl-carbamat 
• 22134-20-9 α,α,α',α'-Tetrachlor-3,5-xylenyl N-methylcarbamat 
• 22134-32-3 α,α'-Dichlor-3,5-xylenyl-N-cyclohexylcarbamat 
• 141036-96-6 Carbonic acid 3,5-dimethyl-phenyl ester 1-phenyl-ethyl ester 
• 36037-34-0 α,α,α',α'-Tetrachlor-3,5-xylenylchlorformat 
• 22132-54-3 α,α'-Dichlor-3,5-xylenylchlorformiat 
• 22132-53-2 α-Chlor-3,5-xylenylchlorformiat 

Relevant academic research and scientific papers

Versatile Cp*Co(III)(LX) Catalyst System for Selective Intramolecular C-H Amidation Reactions

Herein, we report the development of a tailored cobalt catalyst system of Cp*Co(III)(LX) toward intramolecular C-H nitrene insertion of azidoformates to afford cyclic carbamates. The cobalt complexes were easy to prepare and bench-stable, thus offering a convenient reaction protocol. The catalytic reactivity was significantly improved by the electronic tuning of the bidentate LX ligands, and the observed regioselectivity was rationalized by the conformational analysis and DFT calculations of the transition states. The superior performance of the newly developed cobalt catalyst system could be broadly applied to both C(sp2)-H and C(sp3)-H carbamation reactions under mild conditions.

Discovery of (3-Benzyl-5-hydroxyphenyl)carbamates as new antitubercular agents with potent in vitro and in vivo efficacy

A series of 3-amino-5-benzylphenol derivatives were designed and synthesized. Among them, (3-benzyl-5-hydroxyphenyl)carbamates were found to exert good inhibitory activity against M. tuberculosis H37Ra, H37Rv and clinically isolated multidrug-resistant M. tuberculosis strains (MIC = 0.625-6.25 μg/mL). The privileged compounds 3i and 3l showed moderate cytotoxicity against cell line A549. Compound 3l also exhibited potent in vivo inhibitory activity on a mouse infection model via the oral administration. The results demonstrated 3-hydroxyphenylcarbamates as a class of new antitubercular agents with good potential.

Visible-Light-Induced Intramolecular C(sp2)-H Amination and Aziridination of Azidoformates via a Triplet Nitrene Pathway

Catalytic intramolecular C-H amination and aziridination reactions of o-allylphenyl azidoformates have been achieved under visible-light irradiation, providing a mild, clean, and efficient method for the synthesis of useful benzoxazolones and [5.1.0] bicyclic aziridines. Mechanistic studies suggest that a triplet nitrene acts as the reactive intermediate. The chemoselectivity of the reaction, with alkyl olefin aziridination ? electron deficient olefin aziridination ≈ C(sp2)-H amination ? C(sp3)-H amination was observed, which may be instructive in the development of an understanding of visible-light-induced triplet nitrene transformation reactions.

β-type glycosidic bond formation by palladium-catalyzed decarboxylative allylation

The efficient and stereoselective construction of glycosidic linkages is of great significance in carbohydrate chemistry due to the ubiquitous existence of numerous biologically active natural products and saccharides. Although great efforts have been devoted to stereoselective glycosylations in the past few decades, constructing glycosidic bonds with high efficiency and selectivity remains a challenge and continues to be an important area in carbohydrate research. Phenols are widely used as nucleophiles in palladium-catalyzed allylation. In contrast, the possibility of using aliphatic alcohols as nucleophiles is not as thoroughly explored. The modified reaction conditions were then applied to other substrates. Originating from easily prepared carbonates, various glycosides, such as phenolic Oglycosides, thiophenolic S-glycoside, aliphatic O-glycosides, and even disaccharides, were synthesized in good yields by means of a palladium-catalyzed decarboxylative allylation.

AZETIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF METABOLIC AND INFLAMMATORY DISEASES

Compounds are disclosed that have a formula represented by the following: These compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example inflammatory conditions, infectious diseases, autoimmune diseases, diseases involving impairment of immune cell functions, cardiometabolic diseases, and/or proliferative diseases.

Hapten Synthesis and Production of Monoclonal Antibodies to the N-Methylcarbamate Pesticide Methiocarb

With the aim of developing an immunoassay for the detection of the insecticide methiocarb, three compounds with carboxylic spacer arms of different lengths introduced at the carbamate group were synthesized, conjugated to proteins, and used as immunizing haptens in mice. Monoclonal antibodies (MAbs) were subsequently obtained and characterized for their affinity to methiocarb. In the homologous conjugate-coated assay format, MAbs exhibited I5o values in the 1 -10 nM range. Thereafter, a collection of methiocarb haptens with modifications in the aromatic ring structure or in the spacer arm were synthesized to be used as heterologous haptens. These haptens and MAbs were incorporated into several ELISA configurations. Some of the new combinations of immunoreagents and assay format provided a significant improvement in assay sensitivity, reaching I50 values around 0.1 nM. MAbs seem to be very specific for methiocarb, as evidenced by the negligible cross-reactivity shown by methiocarb metabolites. These immunoreagents are very promising analytical tools for the rapid and sensitive determination of methiocarb in food and in the environment.

SYNTHESES DE CARBONATES ET CARBAMATES BENZYLIQUES ET ALLYLIQUES

Different methods for the preparation of carbonates and carbamates derived from 1-phenylethyl, 2-cyclohexenyl and 1-methyl-2-propenyl are described.These conmpounds have been synthesized by the reactions of alcohols, phenols or amines with chloroformiates, imidazolocarbonates or corresponding mixed p-nitrophenylcarbonates. It is shown that these reactions can also be used for the introduction of 1-phenylethyloxycarbonyl - (I), 2-cyclohexenyloxycarbonyl - (II) and 1-methyl-2-propenyloxycarbonyl - (III) groups into alcohols, phenols and amines for the protection of hydroxyls and amino-groups.