36049-77-1

Usage

Uses

Used in Organic Chemistry:
N,N'-Dicyclohexylcarbodiimide methiodide is used as a coupling agent for the synthesis of peptides and proteins, facilitating the formation of amide bonds between carboxylic acids and amino acids.
Used in Biochemistry:
In the field of biochemistry, N,N'-Dicyclohexylcarbodiimide methiodide is utilized for the same purpose, enabling the efficient creation of peptide chains, which are essential components of proteins and other biomolecules.

Upstream product

• 538-75-0 dicyclohexyl-carbodiimide 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Process for the preparation of cepham and cephem compounds

The invention concerns 7β-amino-cepham-3-one-4-carboxylic acid compounds, particularly esters thereof, and the N-substituted, especially N-acylated derivatives of such compounds. They can be used as intermediates, for example, for the manufacture of the corresponding enol ethers and esters, as well as the corresponding 3-unsubstituted 7β-amino-3-cephem-4-carboxylic acid compounds, which show outstanding pharmacological effects.

Process for preparing cephalosporin ethers

The invention relates to O-substituted 7β-amino-3-cephem-3-ol-4-carboxylic acid compounds of the formula STR1 wherein R1a represents hydrogen or an amino protective group R1A and R1b represents hydrogen or an acyl group Ac, or R1a and R1b together represent a bivalent amino protective group, R2 represents hydroxyl or a radical R2A which together with the carbonyl grouping --C(=O)-- forms a protected carboxyl group and R3 represents an optionally substituted hydrocarbon radical or an acyl group, and to 1-oxides of 3-cephem compounds of the formula I, and also to the corresponding 2-cephem compounds of the formula STR2 wherein R1a, R1b, R2 and R3 have the abovementioned meanings, or salts of such compounds with salt-forming groups. 3-Cephem compound of the formula IA, particularly those, in which R1a represents an acyl group, R1b is hydrogen and R2 is hydroxy exhibit pronounced antimicrobial effects, the others, and particularly the 1-oxides of these 3-cephem compounds and the corresponding 2-cephem compounds are useful as intermediates.

7β-Amino-cepham-3-ol-4-carboxylic acid compounds

The invention concerns 7β-amino-cepham-3-ol-4-carboxylic acid compounds, particularly esters thereof, and the N-substituted, especially N-acylated derivatives of such compounds, as well as the 3-O-esters of these compounds. They can be used as intermediates, for example, for the manufacture of the corresponding 3-unsubstituted 7β-amino-3-cephem-4-carboxylic acid compounds, which show outstanding pharmacological effects.