36050-35-8

Basic information

• Product Name: 2-Methyl-3-nitrothiophene-5-carboxylic Acid
• Synonyms: 2-Methyl-3-nitrothiophene-5-carboxylic Acid
• CAS NO: 36050-35-8
• Molecular Formula: C₆H₅NO₄S
• Molecular Weight: 187.1732
• Mol File: 36050-35-8.mol

Chemical Properties

• Melting Point: 180-181 °C
• Boiling Point: 368.4°C at 760 mmHg
• Flash Point: 176.6°C
• Appearance: /
• Density: 1.565g/cm³
• Vapor Pressure: 4.45E-06mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: 2-8°C
• PKA: 3.01±0.10(Predicted)
• CAS DataBase Reference: 2-Methyl-3-nitrothiophene-5-carboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-3-nitrothiophene-5-carboxylic Acid(36050-35-8)
• EPA Substance Registry System: 2-Methyl-3-nitrothiophene-5-carboxylic Acid(36050-35-8)

Safety Data

• Hazardous Substances Data: 36050-35-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-Methyl-3-nitrothiophene-5-carboxylic Acid is used as a building block for the synthesis of new compounds with potential medicinal properties, particularly in the development of antiviral and anticancer agents. Its unique structure allows for the creation of drugs with enhanced therapeutic effects.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Methyl-3-nitrothiophene-5-carboxylic Acid is used as a key intermediate for the production of various organic compounds, leveraging its reactive functional groups to facilitate the formation of complex molecules.
Used in Coordination Chemistry:
2-Methyl-3-nitrothiophene-5-carboxylic Acid is used as a ligand in coordination chemistry, where it forms stable complexes with metal ions, contributing to the study and application of coordination compounds in various fields.
Used in Dyes and Pigments Production:
In the industry of dyes and pigments, 2-Methyl-3-nitrothiophene-5-carboxylic Acid is utilized for its color-producing properties, enabling the creation of a wide range of colored compounds used in various applications, including textiles, plastics, and inks.

InChI:InChI=1/C6H5NO4S/c1-3-4(7(10)11)2-5(12-3)6(8)9/h2H,1H3,(H,8,9)

Upstream product

• 1918-79-2 2-methylthiophene-5-carboxylic acid 
• 7697-37-2 nitric acid 
• 108-24-7 acetic anhydride 
• 98-03-3 thiophene-2-carbaldehyde 
• 554-14-3 2-Methylthiophene 

Downstream Products

• 1001608-59-8 5-[2-(2-fluoro-phenyl)-quinolin-6-yl]-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester 

Relevant articles and documents

Dihydro pyridine compound, its composition, preparation method and use

Disclosed dihydropyridine compounds are the compounds possessing the following general formula (I) as shown in the specification, wherein R1 is selected from hydrogen, halogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkylamino, substituted alkylamino, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic groups, substituted heterocyclic groups, ester group and amide group; R2 is selected from hydrogen, cyanogroup, alkyl, substituted alky, alkenyl, substituted alkenyl and acyl; or R2 and R3 form a fused ring; R3 is selected from alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl; or R3 and R2 or R4 form a fused ring; R4 is selected from hydrogen, alkyl and substituted alkyl; or R4 and R3 or R5 form a fused ring; R5 is selected form alkyl, substituted alky, aryl, substituted aryl, heteroaryl and substituted heteroaryl; or R5 and R4 form a fused ring. The invention also discloses a preparation method of the compounds of the general formula (I), compositions containing the compounds of the general formula (I), and applications of the compositions to medicaments for treating cancers.

THIENOPYRROLE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS

The present disclosure is directed to compounds of formula (Ib) and pharmaceutically acceptable salts thereof, wherein A, Q, R1, R3, R5 and m are as defined herein, which are active as inhibitors of S-Nitrosoglutathione re

FUSED HETEROCYCLIC COMPOUND

The present invention aims to provide a glucokinase activator useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, obesity and the like, and the like. A glucokinase activator containing a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof.

FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE

This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. The invention also provides methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein A is NH or S. Q is a member selected from CR1 and N. X and Y are members independently selected from O, S, CR2, N and NH. R1, R2 and R4 are members independently selected from H and F, provided that at least one member selected from R1, R2 and R4 is F. R6 is a member selected from O?X+ and OH, wherein X+ is a positive ion, which is a member selected from inorganic positive ions and organic positive ions.

ANTIVIRAL AGENTS

Disclosed are compounds and compositions of Formula, (I) and their uses for treating Flaviviridae family virus infections.

TEC KINASE INHIBITORS

Disclosed are compounds of formula (I): (F) wherein Ri, R2, X and Ar are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.

THIENOPYRROLES AS ANTIVIRAL AGENTS

The present invention relates to tetracyclic thienopyrrole compounds of formula (I), wherein Ar, A, D1, D2, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.

Synthesis and biological evaluation of thiophene [3,2-b] pyrrole derivatives as potential anti-inflammatory agents

A series of thiophene [3,2-b] pyrrole derivatives were synthesized and evaluated their abilities to inhibit anti-inflammatory activity. In this series, substituent effects at the N-1, 2 and 5 positions of thiophene [3,2-b] pyrrole were examined. The results obtained are compared to those previously reported anti-inflammatory drugs like Tenidap sodium, Diclofenac sodium and Piroxicam. The results indicated the critical role of the group linked in the N-1 position and 2, 5 positions of thiophene [3,2-b] pyrrole with different functional groups.