360552-56-3Relevant academic research and scientific papers
Synthesis and evaluation of potent pyrrolidine H3 antagonists
Vasudevan, Anil,Conner, Scott E.,Gentles, Robert G.,Faghih, Ramin,Liu, Huaqing,Dwight, Wesley,Ireland, Lynne,Kang, Chae Hee,Esbenshade, Timothy A.,Bennani, Youssef L.,Hancock, Arthur A.
, p. 3055 - 3058 (2002)
The synthesis and biological evaluation of novel antagonists of the rat H3 receptor are described. These compounds differ from prototypical H3 antagonists in that they do not contain an imidazole moiety, but rather a substituted aminopyrrolidine moiety. A systematic modification of the substituents on the aminopyrrolidine ring was performed using pre-formatted precursor sets, where applicable, to afford several compounds with high affinity and selectivity for the H3 receptor.
Cyclic and bicyclic diamino histamine-3 receptor antagonists
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, (2008/06/13)
Compounds of formula (I) compounds of formula (II) compounds of formula (III) and compounds of formula (IV) or pharmaceutically acceptable salts thereof are useful as H3 receptor antagonists. Processes to make the compounds and methods of treat
