360553-46-4Relevant academic research and scientific papers
Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 2: binding preference for D-amino acids motifs.
Faghih, Ramin,Dwight, Wesley,Black, Larry,Liu, Huaqing,Gentles, Robert,Phelan, Kathleen,Esbenshade, Timothy A,Ireland, Lynne,Miller, Thomas R,Kang, Chae-Hee,Krueger, Kathy M,Fox, Gerard B,Hancock, Arthur A,Bennani, Youssef L
, p. 2035 - 2037 (2002)
Structure-activity relationship studies on novel non-imidazole, D-amino acid containing ligands of histamine 3 receptors are presented. A-304121 is a D-alanine piperazine amide with high affinity at the rat H(3) receptor.
1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
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, (2008/06/13)
Compounds of formula I are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands. Also disclosed are histamine-3 receptor ligand compositions and methods of antagonizing or agonizing histamine-3 receptors.
1,3-Disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
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, (2008/06/13)
Compounds of formula I are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands. Also disclosed are histamine-3 receptor ligand compositions and methods of antagonizing or agonizing histamine-3 receptors.
1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
-
, (2008/06/13)
Compounds of formula I are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands. Also disclosed are histamine-3 receptor ligand compositions and methods of antagonizing or agonizing histamine-3 receptors.
Structure - Activity relationships of non-imidazole H3 receptor ligands. Part 1
Faghih, Ramin,Dwight, Wesley,Gentles, Robert,Phelan, Kathleen,Esbenshade, Timothy A,Ireland, Lynne,Miller, Thomas R,Kang, Chae-Hee,Fox, Gerard B,Gopalakrishnan, Sujatha M,Hancock, Arthur A,Bennani, Youssef L
, p. 2031 - 2034 (2007/10/03)
SAR studies for novel non-imidazole containing H3 receptor antagonists with high potency and selectivity for rat H3 receptors are described. A high throughput screening lead, A-923, was further elaborated in a systematic manner to clarify a pharmacophore for this class of aryloxyalkyl piperazine based compounds.
Synthesis and evaluation of potent pyrrolidine H3 antagonists
Vasudevan, Anil,Conner, Scott E.,Gentles, Robert G.,Faghih, Ramin,Liu, Huaqing,Dwight, Wesley,Ireland, Lynne,Kang, Chae Hee,Esbenshade, Timothy A.,Bennani, Youssef L.,Hancock, Arthur A.
, p. 3055 - 3058 (2007/10/03)
The synthesis and biological evaluation of novel antagonists of the rat H3 receptor are described. These compounds differ from prototypical H3 antagonists in that they do not contain an imidazole moiety, but rather a substituted aminopyrrolidine moiety. A systematic modification of the substituents on the aminopyrrolidine ring was performed using pre-formatted precursor sets, where applicable, to afford several compounds with high affinity and selectivity for the H3 receptor.
Cyclic and bicyclic diamino histamine-3 receptor antagonists
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, (2008/06/13)
Compounds of formula (I) compounds of formula (II) compounds of formula (III) and compounds of formula (IV) or pharmaceutically acceptable salts thereof are useful as H3 receptor antagonists. Processes to make the compounds and methods of treat
