360554-66-1

Upstream product

• 851512-56-6 N,N,7,7-tetramethyl-2-oxobicyclo[2.2.1]heptane-1-carboxamide 
• 464-78-8 (1S)-(+)-ketopinic acid 
• 54371-12-9 ketopinic acid chloride 

Relevant academic research and scientific papers

Enantioselective addition of organozinc reagents to carbonyl compounds catalyzed by a camphor derived chiral γ-amino thiol ligand

In this article, the design and synthesis of the chiral camphor derived γ-amino thiol ligand 17 and its application in catalytic enantioselective carbon-carbon forming reactions through the addition of organozinc reagents to carbonyl compounds is described. The catalytic activity and enantioselectivity of ligand 17 is demonstrated in the enantioselective addition of various organozinc reagents to aldehydes and ketoesters, offering the corresponding alcohols in high yields and enantioselectivities. The role of the mercapto group in the highly enantioselective 1,2-addition reaction of organozincs to aldehyde is also discussed.

Enantioselective addition of diethylzinc to aldehydes catalyzed by (1R,2R)-10-(dialkylamino)isoborneols

(1R,2R)-10-Dialkylammoisoborneols, γ-amino alcohol-type ligands, were synthesized from (+)-ketopinic acid. Their catalytic ability as a chiral ligand for enantioselective addition of diethylzinc to aldehydes was evaluated. Among them, the ligand with a 9-