360576-58-5Relevant academic research and scientific papers
2-Arylpyrimidines: Novel CRF-1 receptor antagonists
Yoon, Taeyoung,De Lombaert, Stephane,Brodbeck, Robbin,Gulianello, Michael,Krause, James E.,Hutchison, Alan,Horvath, Raymond F.,Ge, Ping,Kehne, John,Hoffman, Diane,Chandrasekhar, Jayaraman,Doller, Dario,Hodgetts, Kevin J.
scheme or table, p. 4486 - 4490 (2009/04/08)
The design, synthesis and structure-activity relationship studies of a novel series of CRF-1 receptor antagonists, the 2-arylpyrimidines, are described. The effects of substitution on the aromatic ring and the pyrimidine core on CRF-1 receptor binding wer
2-Aryl-3,6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel CRF-1 receptor antagonists
Hodgetts, Kevin J.,Yoon, Taeyoung,Huang, Jianhua,Gulianello, Michael,Kieltyka, Andrzej,Primus, Renee,Brodbeck, Robbin,De Lombaert, Stephane,Doller, Dario
, p. 2497 - 2500 (2007/10/03)
The discovery, synthesis and structure-activity studies of a novel series of 2-arylpyrimidin-4-ones as CRF-1 receptor antagonists is described. These compounds are structurally simple and display appropriate physical properties for CNS agents
5-substituted arylpyrimidines
-
, (2008/06/13)
Arylpyrimidine compounds are provided that can act as selective modulators of CRF receptors. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and
5-Substituted 2-aryl-4-pyrimidinones
-
, (2008/06/13)
Arylpyrimidinone compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and
