36070-75-4

Basic information

• Product Name: 2-CHLORO-5-CYANOPYRAZINE
• Synonyms: 2-CHLORO-5-CYANOPYRAZINE;5-CHLOROPYRAZINE-2-CARBONITRILE;5-Chloro-2-cyanopyrazine;C90110;2-Pyrazinecarbonitrile, 5-chloro-;EOS-61238
• CAS NO: 36070-75-4
• Molecular Formula: C₅H₂ClN₃
• Molecular Weight: 139.54
• Product Categories: Building Blocks;Pyrazine;carbonitrile
• Mol File: 36070-75-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 44-45 ºC
• Boiling Point: 242 ºC
• Flash Point: 100 ºC
• Appearance: /
• Density: 1.43
• Vapor Pressure: 0.036mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -5.41±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-CYANOPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-CYANOPYRAZINE(36070-75-4)
• EPA Substance Registry System: 2-CHLORO-5-CYANOPYRAZINE(36070-75-4)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37
• Hazardous Substances Data: 36070-75-4(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-cyanopyrazine is a chemical compound with the molecular formula C5H2ClN3. It is a pyrazine derivative with a chlorine atom and a cyano group attached to the pyrazine ring. This chemical is used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and organic compounds. It is also used in the production of dyes and pigments. 2-Chloro-5-cyanopyrazine may also have potential applications in the field of material science and organic chemistry due to its unique chemical properties. 2-Chloro-5-cyanopyrazine is primarily used in research and development applications.

InChI:InChI=1/C5H2ClN3/c6-5-3-8-4(1-7)2-9-5/h2-3H

Upstream product

• 768-36-5 2-pyrazinecarboxamide-4-oxide 
• 25594-31-4 3-pyrazinecarbonitrile N-oxide 
• 98-96-4 pyrazinamide 
• 21279-64-1 5-chloro-pyrazine-2-carboxylic acid amide 

Downstream Products

• 21279-64-1 5-chloro-pyrazine-2-carboxylic acid amide 

Relevant articles and documents

Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

A series of 6-hetaryloxy benzoxaborole compounds was designed and synthesized for a structure-activity relationship (SAR) investigation to assess the changes in antimalarial activity which result from 6-aryloxy structural variation, substituent modification on the pyrazine ring, and optimization of the side chain ester group. This SAR study discovered highly potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles (9, 27-34) with IC50s = 0.2-22 nM against cultured Plasmodium falciparum W2 and 3D7 strains. Compound 9 also demonstrated excellent in vivo efficacy against P. berghei in infected mice (ED90 = 7.0 mg/kg).

Synthesis and antimycobacterial evaluation of N-substituted 3-aminopyrazine-2,5-dicarbonitriles

A series of 14 new compounds related to pyrazinamide were synthesized, characterized with analytical data and screened for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium kansasii and two types of Mycobacterium avium. The series comprised of N-substituted 3-aminopyrazine- 2,5-dicarbonitriles derived from 3-chloropyrazine-2,5- dicarbonitrile by nucleophilic substitution of chlorine by various non-aromatic amines (alkylamines, cycloalkylamines and heterocyclic amines). Noteworthy antimycobacterial activity against M. tuberculosis was found among the alkylamino derivatives, for example, 3-(heptylamino)pyrazine-2,5-dicarbonitrile inhibited M. tuberculosis at MIC = 51 lmol/L. 3-(Hexylamino)pyrazine-2,5- dicarbonitrile inhibited M. kansasii at MIC = 218 lmol/L. Basic structure-activity relationships are discussed. A comparison between calculated and experimentally determined lipophilicity parameters within the series is included.

Studies on Pyrazines. Part 10. Substitution Effect on Reaction of Pyrazine N-Oxides with Phosphoryl chloride

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