768-36-5

Usage

Uses

Used in Medical and Scientific Research:
3-Pyrazinecarboxamide 1-oxide is used as a research compound for its potential applications in various medical and scientific fields. Its unique structure and properties make it a valuable tool for studying different biological processes and developing new therapeutic approaches.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 3-Pyrazinecarboxamide 1-oxide may be used as a starting material or intermediate in the synthesis of various drug candidates. Its chemical properties and reactivity can be leveraged to create new compounds with potential therapeutic effects.
Used in Chemical Synthesis:
3-Pyrazinecarboxamide 1-oxide can also be employed in the synthesis of other organic compounds, such as dyes, pigments, and specialty chemicals. Its versatility in chemical reactions allows for the creation of a wide range of products with diverse applications.

InChI:InChI=1/C5H5N3O2/c6-5(9)4-3-8(10)2-1-7-4/h1-3H,(H2,6,9)

Upstream product

• 19847-12-2 2-pyrazine carbonitrile 
• 98-96-4 pyrazinamide 

Downstream Products

• 6863-77-0 3-aminopyrazine 1-oxide 
• 19847-12-2 2-pyrazine carbonitrile 
• 6863-74-7 6-chloropyrazine-2-carbonitrile 
• 36070-75-4 5-chloro-2-pyrazinecarbonitrile 
• 55557-52-3 2-chloro-3-cyanopyrazine 
• 25594-31-4 3-pyrazinecarbonitrile N-oxide 
• 21279-64-1 5-chloro-pyrazine-2-carboxylic acid amide 
• 770-00-3 methylester of pyrazinecarboxylic acid 4-oxide 
• 132274-85-2 5-Cyano-3-phenylsulfanyl-pyrazine-2-carboxylic acid amide 
• 132274-84-1 3-Benzylsulfanyl-5-cyano-pyrazine-2-carboxylic acid amide 
• 36070-79-8 6-chloro-pyarzine-2-carboxamide 
• 1187221-99-3 C-(6-methoxypyrazin-2-yl)methylamine 
• 1187222-00-9 tert-butyl ((6-chloropyrazin-2-yl)methyl)carbamate 
• 1187222-02-1 N-(6-methoxypyrazin-2-ylmethyl)-4-phenoxybenzenesulfonamide 

Relevant academic research and scientific papers

SUBSTITUTED PYRAZ INYLMETHYL SULFONAMIDES FOR USE AS. FUNGICIDES

The present invention relates to the use of pyrazinylmethyl sulfonamides of formula (I) wherein Ra, n, R1, R2, R3, A, Y and D are as defined in the claims, and the N-oxides, and salts thereof for combating harmf

Synthesis, antimycobacterial and antifungal evaluation of 3-arylaminopyrazine-2,5-dicarbonitriles

This paper describes preparation and biological evaluation of pyrazinamide analogues. Pyrazinamide with its simple structure gives a good opportunity for further modification regarding an increase of its antimycobacterial activity. We prepared a series of compounds derived from pyrazine-2,5-dicarbonitrile with arylamino substitution in position 3. All compounds were assayed in vitro against major Mycobacterium and various Fungi species. The best activity was found in 3-{[3-(trifluoromethyl)phenyl]amino}pyrazine-2,5-dicarbonitrile 11 with the value of 6.25 μmol-1 against M. tuberculosis H37Rv and moderate activity against minor Mycobacterium pathogens.

Metal-mediated inhibition of escherichia coli methionine aminopeptidase: Structure-activity relationships and development of a novel scoring function for metal-ligand interactions

We report the discovery of thiabendazole as a potent inhibitor (K 1 = 0.4 μM) of Escherichia coli methionine aminopeptidase (ecMetAP) and the synthesis and pharmacological evaluation of thiabendazole congeners with activity in the upper nanomolar range, Elucidation of the X-ray structure of ecMetAP in complex with thiabendazole and an unrelated inhibitor that was independently described by another group showed that that both compounds bind to an additional CoII ion at the entrance of the active site. This unexpected finding explains the inactivity of the compounds under in vivo conditions. It also allows us to discuss the structure-activity relationships of this series of compounds in a meaningful way, based upon docking runs with an auxiliary metal ion, We describe a new scoring function for the evaluation of metal-mediated inhibitor binding that, unlike the previously used scoring function implemented in the docking program, allows us to distinguish between active and inactive compounds, Finally, conclusions for the structure-based design of in vivo-active inhibitors of ecMetAP are drawn.

Studies on Pyrazines. 18 . A New and Convenient Synthesis of 2-Amino-3-cyanopyrazine

The titled compound, 2-amino-3-cyanopyrazine (1), was prepared by reaction of 3-aminopyrazine 1-oxide (7) with trimethylsilyl cyanide.Furthermore, conditions of individual steps in synthetic route to 7 starting from 2-pyrazinecarboxamide were optimized.