36074-55-2

Upstream product

• 223464-81-1 2-benzyl-6-methanesulfonyl-5-methyl-2,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 1351961-59-5 7-(4-methoxybenzyl)-5-methyl-2,7-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4,6(5H)-dione 
• 100-39-0 benzyl bromide 
• 223464-79-7 2-benzyl-5-methyl-6-methylsulfanyl-2,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 

Downstream Products

• 36074-60-9 2-benzyl-5,7-dimethyl-4,6-dioxo-4,5,6,7-tetrahydropyrazolo<3,4-d>pyrimidine 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2

The present invention relates to compounds of formula I. The compounds are inhibitors of the Src Homolgy-2 phosphatase (SHP2) and thus useful in the treatment of Noonan Syndrome, Leopard Syndrome and cancer.

Synthesis and high resolution proton NMR studies on isomeric N-1-/N-2-, 5,7-trisubstituted-4,6-dioxo-4,5,6,7-tetrahydropyrazolo[3,4-d]pyrimidines

Unambiguous synthesis of all six possible 1/2, 5,7-trisubstituted (monobenzyl, dimethyl)-4,6-dioxo-4,5,67-tetrahydropyrazolo[3,4-d]pyrimidines has been described. High resolution (400 MHz) proton NMR data of these compounds (10, 13, 19, 25a, 25b and 25c)