36075-35-1

Basic information

• Product Name: 7-Methylpyrido[2,3-d]pyriMidine-2,4-diol
• Synonyms: 7-Methylpyrido[2,3-d]pyriMidine-2,4-diol
• CAS NO: 36075-35-1
• Molecular Formula: C8H7N3O2
• Molecular Weight: 177.16008
• Mol File: 36075-35-1.mol

Chemical Properties

• Melting Point: 314-315 °C
• Density: 1.354±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 7-Methylpyrido[2,3-d]pyriMidine-2,4-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Methylpyrido[2,3-d]pyriMidine-2,4-diol(36075-35-1)
• EPA Substance Registry System: 7-Methylpyrido[2,3-d]pyriMidine-2,4-diol(36075-35-1)

Safety Data

• Hazardous Substances Data: 36075-35-1(Hazardous Substances Data)

Upstream product

• 846021-26-9 2-amino-6-methyl nicotinic acid 
• 57-13-6 urea 
• 873-83-6 4-Amino-2,6-dihydroxypyrimidine 
• 5930-98-3 4-trimethylsilyl-3-butyn-2-one 
• 84647-20-1 2-amino-6-methylpyridine-3-carbonitrile 
• 124-38-9 carbon dioxide 
• 120267-14-3 7-methyl-4-oxo-2-thioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid ethyl ester 
• 114402-40-3 7-methyl-4-oxo-2-thioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid 

Relevant articles and documents

Preparation method of heterocyclicpyrimidinedione compound

The invention discloses a preparation method of a heterocyclicpyrimidinedione compound and relates to the technology of medicinal chemistry. The preparation method comprises the following steps: 1) mixing an o-amino formonitrile heterocyclic compound and a catalyst to form a mixture, wherein the catalyst is [HDBN][TFE]; 2) in a CO2 environment, heating the mixture and reacting; 3) when the temperature is reduced to room temperature, adjusting the pH value to neutrality, and extracting, separating and collecting the an organic phase; drying, filtering and then vaporizing; performing column chromatography separation to obtain the heterocyclicpyrimidinedione compound. The preparation method disclosed by the invention has the advantages of low cost, environmental friendliness, simple preparation process and wide application range of substrate.

Ionic liquid promoted synthesis of heterocycle-fused pyrimidine-2,4(1H,3H)-diones utilising CO2

An efficient ionic liquid system was developed for the preparation of various heterocycle-fused pyrimidine-2, 4(1H,3H)-diones in moderate to excellent yields (52–95%). It was found that [HDBN+][TFE?], a simple and easily prepared ionic liquid, could act as both the solvent and reaction promoter, and that the reactions could be efficiently carried out at atmospheric pressures of CO2.

One or two-step Bohlmann-Rahtz heteroannulation of 6-aminouracil derivatives for the synthesis of pyrido[2,3-d]pyrimidines

The Michael addition-cyclodehydration of a 6-aminouracil and alkynone proceeds to give 5-deazapterin derivatives with total control of regiochemistry. This simple and facile cyclocondensation process is catalyzed by zinc(II) bromide or ytterbium(III) trifluoromethanesulfonate at 110°C, providing the heteroannulated products in up to 94% yield.