360769-79-5Relevant academic research and scientific papers
Small-molecular inhibitors of Ca2+-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene
Murasawa, Shinpei,Sato, Shinichi,Noguchi-Yachide, Tomomi,Hashimoto, Yuichi,Iuchi, Katsuya,Sodeoka, Mikiko,Dodo, Kosuke,Yokomatsu, Tsutomu,Aoyama, Hiroshi
, p. 6384 - 6393,10 (2012/12/11)
A structure consisting of substituted hydantoin linked to a 5-(halophenyl)furan-2-yl group via an amide bond was identified as a promising scaffold for development of low-molecular-weight therapeutic agents to treat vascular dysfunction, including ischemia/reperfusion injury. Among the compounds synthesized, 5-(3,5-dichlorophenyl)-N-{2,4-dioxo-3-[(pyridin-3-yl)methyl] imidazolidin-1-yl}-2-furamide (17) possessed the most potent inhibitory activity against Ca2+-induced mitochondrial swelling. The structural development, synthesis and structure-activity relationship of these compounds are described.
