360770-36-1

Upstream product

• 890901-69-6 (2S)-3-hydroxy-2-({2-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]acetyl}amino)propanoic acid 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 139166-79-3 1-thyminylacetic acid pentafluorophenyl ester 
• 20924-05-4 thymidyl acetic acid 
• 890901-68-5 C₁₆H₂₉N₃O₆Si₂ 

Relevant academic research and scientific papers

Synthesis of a novel ester analog of nucleic acids bearing a serine backbone

A novel analog of nucleic acids bearing an optically active serine ester backbone, serine-based nucleobase-linked polyester (SNE), was synthesized. Monomers containing a thymine base were synthesized from l- and d-serines. Furthermore, reaction conditions

Peptide nucleic acids and their phosphonate analogues: II 1. Synthesis and physicochemical properties of hybrids containing serine and 4-hydroxyproline residues

DNA mimics representing hybrids of peptide nucleic acids (PNA) or PNA phosphonate analogues (pPNA) with hydroxyamino acid derivatives, L-serine and L-4-trans-hydroxyproline, were synthesized. Preparative synthesis of monomers and some heterodimers derived from serine and hydroxyproline was developed. The corresponding mimic oligomers including pyrene-containing derivatives were prepared by the solid-phase automated synthesis. Ability of the resulting NA analogues to hybridize specifically to the DNA and RNA complementary strands was studied. It was shown that homothymine hybrids containing PNA or pPNA monomers alternating with hydroxyproline-derived monomers can form stable complexes with the complementary oligonucleotides, whose melting temperatures are close to those of equivalent PNA complexes.

Novel oligonucleotide analogues derived from serine and 4-hydroxyproline

A set of DNA analogues derived from serine and 4-hydroxyproline and containing carboxamidomethyl phosphonate and carboxamidophosphate bonds between monomeric units was synthesized.