139166-79-3Relevant academic research and scientific papers
Synthesis of a novel ester analog of nucleic acids bearing a serine backbone
Murata, Asako,Wada, Takeshi
, p. 2933 - 2936 (2006)
A novel analog of nucleic acids bearing an optically active serine ester backbone, serine-based nucleobase-linked polyester (SNE), was synthesized. Monomers containing a thymine base were synthesized from l- and d-serines. Furthermore, reaction conditions
Duplex strand formation using alternating copolymers
Nakade, Hiroshi,Ilker, M. Firat,Jordan, Brian J.,Uzun, Oktay,LaPointe, Nicholas L.,Coughlin, E. Bryan,Rotello, Vincent M.
, p. 3271 - 3273 (2005)
The regular arrangement of complementary diaminopyridine-thymine (DAP-THY) on alternating copolymers permits cooperative binding events and the effective formation of well-controlled micrometre-scale aggregates. The Royal Society of Chemistry 2005.
Acyclic nucleotide analogues on the basis of phosphonic acids
Efimtseva,Mikhailov,Fomicheva,Meshkov,Rodionov,Khomutov,De Clercq
, p. 12 - 16 (2007/10/03)
The synthesis of novel nucleotide analogues on the basis of ethylphosphonic acids was described. A rigid structural element, an amide, or a double bond, was characteristic of the compounds synthesized. The antiviral and cytotoxic activities of these compo
Synthesis and photochemical behavior of peptide nucleic acid dimers and analogues containing 4-thiothymine: Unprecedented (5-4) photoadduct reversion
Clivio, Pascale,Guillaume, Dominique,Adeline, Marie-Thérèse,Hamon, Jeanine,Riche, Claude,Fourrey, Jean-Louis
, p. 1157 - 1166 (2007/10/03)
Pna dimers 1, 5, containing either 4-thiothymine or N3-methyl- 4-thiothymine, were prepared, and the crystal structure of compound 3 was established. With regard to their photochemistry none of these PNA analogues were able to fully mimic the p
New approach to solid phase synthesis of polyamide nucleic acids analogues (PNA) and PNA-DNA conjugates
Stetsenko, Dmitry A.,Lubyako, Elena N.,Potapov, Viktor K.,Azhikina, Tatyana L.,Sverdlov, Evgeny D.
, p. 3571 - 3574 (2007/10/03)
New version of sequential DNA and polyamide solid phase synthesis is applied to the preparation of PNA and PNA-DNA conjugates bearing free 3'-end. N-Mmt protected uracil and thymine PNA monomers are obtained in high yields. Novel support derived from TSK
Structure-activity studies of the binding of modified peptide nucleic acids (PNAs) to DNA
Hyrup, Birgitte,Egholm, Michael,Nielsen, Peter E.,Wittung, Pernilla,Nordén, Bengt,Buchardf, Ole
, p. 7964 - 7970 (2007/10/02)
Peptide nucleic acid (PNA) oligomers where one of the repeating backbone units is extended with a methylene group to either N-(2-aminoethyl)-β-alanine or N-(3-aminopropyl)glycine were prepared. Alternatively, the linker to the nucleobase was extended from
