360774-14-7

Basic information

• Product Name: 2-(Benzyloxy)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile
• Synonyms: 2-(Benzyloxy)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile
• CAS NO: 360774-14-7
• Molecular Weight: 250.3
• Mol File: 360774-14-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(Benzyloxy)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Benzyloxy)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile(360774-14-7)
• EPA Substance Registry System: 2-(Benzyloxy)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile(360774-14-7)

Safety Data

• Hazardous Substances Data: 360774-14-7(Hazardous Substances Data)

Usage

General Description

2-(Benzyloxy)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile is a chemical compound with the molecular formula C21H19N2O and a molecular weight of 313.39 g/mol. It is a heterocyclic compound containing a cyclopenta[b]pyridine ring system, with a benzyloxy group and a carbonitrile group attached at specific positions. 2-(Benzyloxy)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile is used in the field of medicinal chemistry and drug development due to its potential biological activity. It may be used as a building block or intermediate in the synthesis of pharmaceuticals targeting specific biological pathways or receptors. However, further research and studies are required to fully understand its properties and potential applications.

Upstream product

• 100-44-7 benzyl chloride 
• 108106-97-4 2-oxo-2,5,6,7-tetrahydro-3-cyano-1H-cyclopenta[b]pyridine-3-carbonitrile 
• 100-39-0 benzyl bromide 
• 120-92-3 cyclopentanone 

Downstream Products

• 201274-49-9 2-(Benzyloxy)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbaldehyde 
• 201274-51-3 1-[2-(Benzyloxy)-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl]-3-[6-(benzyloxy)pyridin-2-yl]prop-2-yn-1-ol 
• 234752-98-8 2-(Benzyloxy)-3-(3-[6-(benzyloxy)pyridin-2-yl]-1-{[tert-butyl(dimethyl)silyl]oxy}prop-2-ynyl)-6,7-dihydro-5H-cyclopenta[b]pyridine 

Relevant articles and documents

Zinc (II)-mediated selective O-benzylation of 2-Oxo-1,2-dihydropyridines systems

The selective O-benzylation of 2-oxo-1,2-dihydropyridines plays a critical role in organic synthesis of natural products and biological active molecules. Herein we report a novel ternary system of ZnO, ZnCl2 and N,N-diisopropylethylamine (DIEA), that is highly effective for selective O-benzylation of 2-oxo-1,2-dihydropyridines using abundant substituted benzyl halides and related substituted 2-oxo-1,2-dihydropyridines compounds. This process allows access to a variety of O-benzyl products under mild reaction conditions, which are important synthetic intermediates in the protection of functional groups, and represents a new method toward the development for the O-benzylation of 2-oxo-1,2-dihydropyridines.

Fusicoccin ring system by [4 + 4] cycloaddition. 2. A model study

A synthetic approach to fusicoccin A utilizing intramolecular photocycloaddition of tethered 2-pyridones has been completed. This study has led to the first solvent-dependent 2-pyridone photocycloaddition yielding either cis or trans products. Epoxidation of the cis photoproduct is selective for the disubstituted alkene, stabilizes the product, and is properly located for installation of the trans-1,2-diol. Activation of the secondary amide by reaction with an isocyanate led to the reduction of the neopentyl amide carbonyl to a methyl group.