360778-83-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 360778-82-1 (R)-(2-Hydroxy-3,5-dimethoxy-4-methyl-phenyl)-((R)-2-hydroxy-2-methyl-1-phenyl-propylamino)-acetic acid methyl ester 
• 24461-61-8 (R)-Phenylglycine methyl ester 
• 875-74-1 (R)-phenylglycine 
• 141190-94-5 (R)-N-(tert-butoxycarbonyl)phenylglycine methyl ester 
• 360778-77-4 3-(2-hydroxy-3,5-dimethoxy-4-methylphenyl)-6,6-dimethyl-5-phenylmorpholin-2-one 
• 360778-68-3 (R)-6,6-Dimethyl-5-phenyl-morpholin-2-one 
• 360778-69-4 agent lactone 
• 223906-33-0 ((R)-2-hydroxy-2-methyl-1-phenyl-propyl)-carbamic acid tert-butyl ester 
• 110480-87-0 (R)-1-amino-2-methyl-1-phenyl-propan-2-ol 

Relevant academic research and scientific papers

Synthesis of optically active α-arylglycines: Stereoselective Mannich-type reaction with a new chiral template

Mannich-type reaction of phenols with iminolactone 4, readily prepared from commercially available phenylglycine, proceeded with high stereoselectivity to give α-arylglycine derivatives. The reaction was also applicable to other electron-rich aromatic compounds and aryl boronic acids. These adducts could be readily converted to the corresponding optically active α-arylglycines.