360785-81-5Relevant academic research and scientific papers
Incorporation of α- and β-LNA (Locked nucleic acid) monomers in oligodeoxynucleotides with polarity reversals
Christensen, Nanna K.,Dahl, Britta M.,Nielsen, Poul
, p. 1765 - 1768 (2001)
The thymidine monomers of LNA with both α- and β-configuration are incorporated with polarity reversals (i.e., with 3′-3′ and 5′-5′ junctions) in oligodeoxynucleotides with β- and α-configuration, respectively. A 5′-O-phosphoramidite of the β-LNA monomer is synthesised. Large destabilisations of duplexes with both complementary DNA and RNA are observed for oligodeoxynucleotides containing the α-LNA monomer, whereas a duplex with complementary RNA of an α-oligodeoxynucleotide containing the β-LNA monomer is not destabilised.
