239808-67-4

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 2923-28-6 silver trifluoromethanesulfonate 

Downstream Products

• 149672-47-9 (3'S,5'R)-1-<2'-deoxy-5'-O-<(4,4'-dimethoxytriphenyl)methyl>-3',5'-ethano-β-D-ribofuranosyl>thymine 
• 200931-81-3 1-{(1aR,1bS,3R,4aS,5aR)-1a-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-4a-hydroxy-octahydro-2-oxa-cyclopropa[a]pentalen-3-yl}-5-methyl-1H-pyrimidine-2,4-dione 
• 383191-88-6 (1S,3S,4R,6R,7R,8R,9R)-8-Benzoyloxy-9-(4,4'-dimethoxytrityloxy)-7-hydroxy-4-(thymin-1-yl)-2,5-dioxatricyclo[4.2.1.0^3,7]nonane 
• 440115-12-8 (5'R)-N⁴-benzoyl-1-[5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-deoxy-3'-C,5'-C-[(5'-C,6'-C-methano)ethano]-β-D-ribofuranosyl]cytosine 
• 231951-10-3 N-[6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-8-(tert-butyl-dimethyl-silanyloxy)-2-oxa-bicyclo[3.2.1]oct-5-yl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide 
• 231951-11-4 N-(9-{[6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-8-(tert-butyl-dimethyl-silanyloxy)-2-oxa-bicyclo[3.2.1]oct-5-ylcarbamoyl]-methyl}-9H-purin-6-yl)-benzamide 
• 512782-17-1 N-(1-{[6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-8-(tert-butyl-dimethyl-silanyloxy)-2-oxa-bicyclo[3.2.1]oct-5-ylcarbamoyl]-methyl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-4-tert-butyl-benzamide 
• 174692-14-9 Succinic acid mono-[(2S,3aS,6R,6aR)-6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-cyclopenta[b]furan-3a-yl] ester 
• 174692-15-0 Succinic acid mono-{(2S,3aS,6R,6aR)-2-(6-benzoylamino-purin-9-yl)-6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexahydro-cyclopenta[b]furan-3a-yl} ester 
• 1146340-54-6 5'-O-(4,4'-dimethoxytrityl)-3'-C,4'-C-(3-oxabutylene)thymidine 
• 1446748-42-0 C₅₄H₆₄N₂O₁₁Si 
• 1446748-44-2 C₅₅H₅₆N₂O₁₃S 
• 1446748-45-3 C₄₈H₄₈N₂O₁₀ 
• 1454652-29-9 C₃₉H₃₇NO₅S 

Relevant academic research and scientific papers

Synthesis and thermal stabilities of oligonucleotides containing 2′-: O,4′- C -methylene bridged nucleic acid with a phenoxazine base

We designed and synthesized a novel artificial 2′-O,4′-C-methylene bridged nucleic acid (2′,4′-BNA/LNA) with a phenoxazine nucleobase and named this compound BNAP. Oligodeoxynucleotide (ODN) containing BNAP showed higher binding affinities toward compleme

2′,4′-BNA/LNA with 9-(2-Aminoethoxy)-1,3-diaza-2-oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance**

Artificial nucleic acids are widely used in various technologies, such as nucleic acid therapeutics and DNA nanotechnologies requiring excellent duplex-forming abilities and enhanced nuclease resistance. 2′-O,4′-C-Methylene-bridged nucleic acid/locked nuc

Synthesis and evaluation of artificial nucleic acid bearing an oxanorbornane scaffold

Natural oligonucleotides have many rotatable single bonds, and thus their structures are inherently flexible. Structural flexibility leads to an entropic loss when unwound oligonucleotides form a duplex with single-stranded DNA or RNA. An effective approa

6′-Fluoro[4.3.0]bicyclo nucleic acid: Synthesis, biophysical properties and molecular dynamics simulations

Here we report on the synthesis, biophysical properties and molecular modeling of oligonucleotides containing unsaturated 6'-fluoro[4.3.0]bicyclo nucleotides (6'F-bc4,3-DNA). Two 6'F-bc4,3 phosphoramidite building blocks (T and C) were synthesized startin

Base-resolution analysis of 5-hydroxymethylcytidine by selective oxidation and reverse transcription arrest

While 5-hydroxymethylcytidine in RNA (hm5C) is associated with cellular development and differentiation, its distribution and biological function remain largely unexplored because suitable detection methods are lacking. Here, we report a base-r

Access to 1′-Amino Carbocyclic Phosphoramidite to Enable Postsynthetic Functionalization of Oligonucleotides

We report a synthesis of a carbocyclic, abasic RNA phosphoramidite decorated with an amino functionality. The building block was efficiently incorporated into an RNA oligonucleotide in a site-specific manner, followed by deprotection to a free amino group

Synthesis of the 5-methyluridine monomer of 3-O,4-C-ethyleneoxy-bridged nucleic acid

– A novel bridged nucleic acid, 3-O,4-C-ethyleneoxy-bridged nucleic acid (3,4-EoNA), forming 2,5-linkage with the flanking nucleotides in oligonucleotides was designed. The 3,4-EoNA is expected to improve the biophysical properties of the oligonucleotides

Synthesis and properties of 2'-deoxy-trans-3'4'-BNA with S-type sugar puckering

2'-deoxy-trans-3',4'-BNA monomer, which was previous synthesized as part of a study on bridged nucleic acids with S-type sugar puckering, was introduced into an oligodeoxynucleotide using phosphoramidite chemistry, and the hybridization ability of the 2'-

Synthesis and properties of trans-3′,4′-bridged nucleic acids having typical S-type sugar conformation

The synthesis of nucleoside analogues with a conformationally restricted sugar moiety is of great interest. The present research describes the synthesis of BNA (bridged nucleic acid) monomers 1 and 2 bearing a 4,7-dioxabicyclo[4.3.0] nonane skeleton and a methoxy group at the C2' position. Conformational analysis showed that the sugar moiety of these monomers is restricted in a typical S-type conformation. It was difficult to synthesize the phosphoramidite derivative of the ribo-type monomer 1, while the phosphoramidite of the arabino-type monomer 2 was successfully prepared and incorporated into oligodeoxynucleotides (ODNs). The hybridization ability of the obtained ODN derivatives containing 2 with complementary strands was evaluated by melting temperature (Tm) measurements. As a result, the ODN derivatives hybridized with DNA and RNA complements in a sequence-selective manner, though the stability of the duplexes was lower than that of the corresponding natural DNA/DNA or DNA/RNA duplex.