36082-04-9Relevant articles and documents
The Conversion of α-Bromo-β-Dicarbonyls to Vicinal Tricarbonyls Using Dimethyldioxirane and Base
Coats, Steven J.,Wasserman, Harry H.
, p. 7735 - 7738 (1995)
Vicinal tricarbonyls are prepared from α-bromo-β-dicarbonyl precursors by base promoted oxygen transfer from dimethyldioxirane.The α-bromo-β-dicarbonyls were prepared by the reaction of CuBr2 and benzene (Koser's reagent) with a β-dicarbonyl system.
Synthesis of (?)-Hebelophyllene E: An Entry to Geminal Dimethyl-Cyclobutanes by [2+2] Cycloaddition of Alkenes and Allenoates
Wiest, Johannes M.,Conner, Michael L.,Brown, M. Kevin
supporting information, p. 4647 - 4651 (2018/03/27)
The first synthesis of hebelophyllene E is presented, along with assignment of its previously unknown relative configuration through synthesis of epi-ent-hebelophyllene E. Development of a catalytic enantioselective [2+2] cycloaddition of alkenes and alle
Total synthesis of epothilone D: The nerol/macroaldolization approach
Wessjohann, Ludger A.,Scheid, Guenther O.,Eichelberger, Uwe,Umbreen, Sumaira
, p. 10588 - 10595 (2013/11/19)
A highly convergent and stereocontrolled synthesis of epothilone D (4) is reported. Key features are a cheap and Z-selective synthesis of the northern half based on nerol and acetoacetate and chromium(II)-mediated Reformatsky reactions as a powerful tool for chemoselective asymmetric carbon-carbon bond formations, including an unusual stereospecific macroaldolization.
