361-09-1

Basic information

• Product Name: Sodium cholate
• Synonyms: SODIUM, (R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-TRIHYDROXY-10,13-DIMETHYL-HEXADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-17-YL)-PENTANOATE;SODIUM CHOLATE;SODIUM CHOLEATE;17-(1-Methyl-3-carboxypropyl)etiocholane-3;17-beta-(1-methyl-3-carboxypropyl)etiocholane-3alpha,7alpha,12alpha-triol;3,7,12-trihydroxy-,(3-alpha,5-beta,7-alpha,12-alpha)-cholan-24-oicaci;3,7,12-trihydroxy-,(3alpha,5beta,7alpha,12alpha)-cholan-24-oicaci;3,7,12-Trihydroxy-5-chloanicacid
• CAS NO: 361-09-1
• Molecular Formula: C₂₄H₃₉O₅*Na
• Molecular Weight: 430.55
• EINECS: 206-643-5
• Product Categories: Anionic Surfactants;Anionic Surfactants (for Biochemistry);Bile Acids;Biochemistry;Carboxylate (Surfactants);Functional Materials;Steroids;Surfactants;Surfactants (for Biochemistry)
• Mol File: 361-09-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 583.9 °C at 760 mmHg
• Flash Point: 321 °C
• Appearance: White to off-white/Powder
• Density: 0.999 at 20.09℃
• Vapor Pressure: 4.59E-16mmHg at 25°C
• Refractive Index: 35 ° (C=0.6, EtOH)
• Storage Temp.: +15C to +30C
• Solubility: DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly), Water
• Water Solubility: 150 g/L (20 ºC)
• Stability: Hygroscopic
• CAS DataBase Reference: Sodium cholate(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium cholate(361-09-1)
• EPA Substance Registry System: Sodium cholate(361-09-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-36-26
• WGK Germany: 3
• RTECS: FZ9600000
• TSCA: Yes
• Hazardous Substances Data: 361-09-1(Hazardous Substances Data)

Usage

Chemical Properties

white to off-white powder

Uses

Sodium cholate is a non-denaturing detergent used for membrane protein extraction.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NazO. See also CHOLIC ACID.

InChI:InChI=1/C24H40O5.Na/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);/q;+1/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;/m1./s1

Upstream product

• 81-25-4 cholic acid 

Downstream Products

• 2304-89-4 7α,12α-dihydroxy-3-oxocholanoic acid 
• 911-40-0 7-ketodeoxycholic acid 
• 2304-92-9 3,7-diketo-12α-hydroxy-5β-cholan-24-oic acid 
• 13587-11-6 3-oxo-7α,12α-dihydroxy-4-cholen-24-oic acid 
• 1109215-60-2 1-[4-(3α,7α,12α-trihydroxy-5β-cholan)butoxy]-2,5-diiodo-4-methoxybenzene 
• 2458-08-4 3α,7α-dihydroxy-12-oxo-5β-cholan-24-oic acid 
• 81-23-2 dehydrocholic acid 
• 517-33-9 7,12-dioxolitocholic acid 

Relevant articles and documents

Synthesis, characterization and biological activity of hydroxyl- bisphosphonic analogs of bile acids

Bisphosphonates (BPs) are now the most widely used drugs for diseases associated with increased bone resorption, such as osteoporosis, and tumor bone diseases. A significant drawback of the BPs is their poor oral absorption that is enhanced by the presence of bile acid substituents in the bisphosphonate framework, with no toxic effects. A straightforward synthesis of bile acid-containing hydroxy-bisphosphonates and a full characterization of these pharmaceutically important molecules, including an evaluation of affinity and the mechanism of binding to hydroxyapatite, is presented. The biological activity of bile acid-containing bisphosphonate salts was determined using the neutral-red assay on the L929 cell line and primary cultures of osteoclasts. The bioactivity of the new compounds was found superior than bisphosphonates of established activity.