361-92-2

Usage

Uses

Used in Organic Synthesis:
2'-Fluoro-biphenyl-2-carboxylic acid is used as a building block in organic synthesis for the creation of various organic compounds. Its unique structure and functional groups contribute to the synthesis of a wide range of chemical products.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2'-Fluoro-biphenyl-2-carboxylic acid is utilized as a key intermediate in the development of new drugs. Its specific structural features and reactivity can be leveraged to design and synthesize pharmaceutical compounds with potential therapeutic applications.
Used in Agrochemicals:
2'-Fluoro-biphenyl-2-carboxylic acid is also used in the synthesis of agrochemicals, where its unique properties can be harnessed to develop new pesticides or other agricultural chemicals that can improve crop protection and yield.

Upstream product

• 88-67-5 2-Iodobenzoic acid 
• 1993-03-9 o-fluorophenylboronic acid 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 80254-80-4 methyl 2′-fluoro-[1,1′-biphenyl]-2-carboxylate 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 14938-35-3 4-n-pentylphenol 
• 1072-85-1 o-fluorobromobenzene 
• 124-38-9 carbon dioxide 

Downstream Products

• 2005-10-9 6H-benzo[c]chromen-6-one 

Relevant academic research and scientific papers

Identification of 2-(2′-fluoro-[1,1′-biphenyl]-2-yl)acetamide as a Sodium Valproate-like broad spectrum anti-epileptic drug candidate

By further optimizing compound A [2′-fluoro-N-methyl-[1,1′-biphenyl]-2-sulfonamide], we identified DSP-0565 [2-(2′-fluoro-[1,1′-biphenyl]-2-yl)acetamide, 17a] as a strong, broad-spectrum anti-epileptic drug (AED) candidate. Our efforts mainly focused on finding an alternative polar group for the sulfonamide in order to improve ADME profile of compound A including good metabolic stability and no reactive metabolic production. This led to the identification of biphenyl acetamide as a new scaffold for development of broad-spectrum AED candidates. DSP-0565 showed anti-convulsant activity in various models (scPTZ, MES, 6 Hz and amygdala kindling) with good safety margin, and was therefore selected as a clinical candidate.

General and practical carboxyl-group-directed remote C-H oxygenation reactions of arenes

Two methods for remote aromatic C-H oxygenation reactions, have been developed. Method1, the Cu-catalyzed oxygenation reaction, is highly efficient for cyclization of electron-neutral and electron-rich biaryl carboxylic acids into 3,4-benzocoumarins. Method2, the K2S2O 8-mediated oxygenation reaction, is more general and practical for cyclization of substrates with electron-donating and -withdrawing groups (see scheme). Copyright

Pd-catalyzed C-H lactonization for expedient synthesis of biaryl lactones and total synthesis of cannabinol

A practical Pd(II)/Pd(IV)-catalyzed carboxyl-directed C-H activation/C-O cyclization to construct biaryl lactones has been developed. The synthetic utility of this new reaction was demonstrated in an atom-economical and operationally convenient total synthesis of the natural product cannabinol from commercially available starting materials, with the newly developed method used for two key steps.

Pd-EDTA as an efficient catalyst for Suzuki-Miyaura reactions in water

PdCl2-EDTA complex 1 is an efficient catalyst for the Suzuki-Miyaura reactions of aryl and heteroaryl halides with aryl(heteroaryl)boronic acids in water at 20-100°C. Aryl iodides and bromides undergo the cross-coupling with turnover numbers (T

Halogen-containing, optically active liquid crystal compound and liquid crystal composition containing same

A novel optically active liquid crystal compound and a liquid crystal composition containing the same are provided, which compound is expressed by the formula STR1 wherein R1 is alkyl or alkoxy of 4-18 C; R2 is alkyl, alkoxy, acyl or alkoxymethyl of 4-18 C; but either one of R1 or R2 is an optically active group; either one of X1 or X2 is halogen atom and the other is H; m and n each are 0 or 1 and m+n is 0 or 1.