361-92-2

Basic information

• Product Name: 2'-FLUORO-BIPHENYL-2-CARBOXYLIC ACID
• Synonyms: RARECHEM AL BE 1361;CHEMBRDG-BB 4400443;2'-FLUORO-BIPHENYL-2-CARBOXYLIC ACID;2'-FLUORO[1,1'-BIPHENYL]-2-CARBOXYLIC ACID;AKOS BAR-1428;2'-fluorobiphenyl-2-carboxylic acid(SALTDATA: FREE);2-(2-Fluorophenyl)benzoic acid
• CAS NO: 361-92-2
• Molecular Formula: C13H9FO2
• Molecular Weight: 216.21
• Mol File: 361-92-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2'-FLUORO-BIPHENYL-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-FLUORO-BIPHENYL-2-CARBOXYLIC ACID(361-92-2)
• EPA Substance Registry System: 2'-FLUORO-BIPHENYL-2-CARBOXYLIC ACID(361-92-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 361-92-2(Hazardous Substances Data)

Usage

General Description

2'-Fluoro-biphenyl-2-carboxylic acid is a chemical compound with the molecular formula C13H9FO2. It is a derivative of biphenyl, consisting of a biphenyl core with a carboxylic acid and a fluorine atom substituted at the 2' position. 2'-FLUORO-BIPHENYL-2-CARBOXYLIC ACID is used in organic synthesis and pharmaceutical research. Its unique structure and reactive functional groups make it a valuable building block for the synthesis of various organic compounds, including pharmaceutical intermediates and agrochemicals. Additionally, its fluoro-substituted biphenyl core may provide interesting properties for drug discovery and development.

Upstream product

• 1072-85-1 o-fluorobromobenzene 
• 124-38-9 carbon dioxide 
• 1993-03-9 o-fluorophenylboronic acid 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 80254-80-4 methyl 2′-fluoro-[1,1′-biphenyl]-2-carboxylate 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 14938-35-3 4-n-pentylphenol 
• 88-67-5 2-Iodobenzoic acid 

Downstream Products

• 2005-10-9 6H-benzo[c]chromen-6-one 

Relevant articles and documents

Identification of 2-(2′-fluoro-[1,1′-biphenyl]-2-yl)acetamide as a Sodium Valproate-like broad spectrum anti-epileptic drug candidate

By further optimizing compound A [2′-fluoro-N-methyl-[1,1′-biphenyl]-2-sulfonamide], we identified DSP-0565 [2-(2′-fluoro-[1,1′-biphenyl]-2-yl)acetamide, 17a] as a strong, broad-spectrum anti-epileptic drug (AED) candidate. Our efforts mainly focused on finding an alternative polar group for the sulfonamide in order to improve ADME profile of compound A including good metabolic stability and no reactive metabolic production. This led to the identification of biphenyl acetamide as a new scaffold for development of broad-spectrum AED candidates. DSP-0565 showed anti-convulsant activity in various models (scPTZ, MES, 6 Hz and amygdala kindling) with good safety margin, and was therefore selected as a clinical candidate.

Pd-catalyzed C-H lactonization for expedient synthesis of biaryl lactones and total synthesis of cannabinol

A practical Pd(II)/Pd(IV)-catalyzed carboxyl-directed C-H activation/C-O cyclization to construct biaryl lactones has been developed. The synthetic utility of this new reaction was demonstrated in an atom-economical and operationally convenient total synthesis of the natural product cannabinol from commercially available starting materials, with the newly developed method used for two key steps.

Halogen-containing, optically active liquid crystal compound and liquid crystal composition containing same

A novel optically active liquid crystal compound and a liquid crystal composition containing the same are provided, which compound is expressed by the formula STR1 wherein R1 is alkyl or alkoxy of 4-18 C; R2 is alkyl, alkoxy, acyl or alkoxymethyl of 4-18 C; but either one of R1 or R2 is an optically active group; either one of X1 or X2 is halogen atom and the other is H; m and n each are 0 or 1 and m+n is 0 or 1.