36107-06-9Relevant articles and documents
Synthesis, characterization and antioxidant activity of bis (arylsulfonylmethyl/arylaminosulfonylmethylazolyl) pyridines
Gunthanakkala, Anil Kumar,Mangali, Madhu Sekhar,Venkatapuram, Padmavathi,Adivireddy, Padmaja
, p. 4164 - 4174 (2020/09/07)
A new class of bis(arylsulfonylmethylazolyl)pyridines and bis(arylaminosulfonylmethyl-azolyl)pyridines were synthesized from the synthetic intermediates methyl arylsulfonylacetic acid hydrazide and methyl arylaminosulfonylacetic acid hydrazide adopting a green methodology-ultrasonication. All the synthesized compounds were resulted in higher yield and in shorter reaction times. The spectral parameters such as IR, 1H NMR, 13C NMR, mass and microanalyzes were used to determine the structures of all the synthesized compounds and were assayed for antioxidant activity. The bis(arylaminosulfonylmethylazolyl)pyridines showed higher radical scavenging activity than the bis(arylsulfonylmethylazolyl)pyridines. Besides, unsubstituted, and methyl substituted compounds exhibited greater activity. Among all the tested compounds 8b and 11b were identified as potential antioxidants.
Synthesis and antimicrobial activity of pyrazolyl 1,3,4-oxadiazoles
Padmavathi, Venkatapuram,Reddy, Gali Sudhakar,Reddy, Guda Dinneswara,Payani, Thalari
scheme or table, p. 482 - 493 (2010/04/06)
The pyrazolyl oxadiazoles are synthesized from arylsulfonylacetic acid methyl ester and benzylsulfonylacetic acid methyl ester. Preliminary antimicrobial screening of the compounds showed that bis heterocycles with a chloro-substituted benzyl moiety exhibited high activity. Copyright Taylor & Francis Group, LLC.
Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles
Padmavathi,Sudhakar Reddy,Padmaja,Kondaiah,Ali-Shazia
experimental part, p. 2106 - 2112 (2009/09/25)
A new class of 1,3,4-oxadiazoles were prepared from acid hydrazides on treatment with different carboxylic acids in the presence of phosphorus oxychloride. Interconversion of oxadiazoles to thiadiazoles and triazoles was carried out with appropriate reagents. The antimicrobial and cytotoxic activities of compounds 7a-d to 12a-d were tested. Compounds 10d and 12d showed pronounced antimicrobial activity. Further, compound 10d exhibited maximum cytotoxicity.
TRIAZOLE DERIVATIVE OR SALT THEREOF
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Page/Page column 31, (2010/11/27)
[Problem] There is provided a compound which can be used for therapy of diseases in which 11 β-hydroxysteroid dehydrogenase type 1(11β-HSD1) participates, in particular diabetes, insulin resistance. [Means for Solution] It has been found that a triazole derivative wherein the triazole ring is substituted with a trisubstituted methyl group in the 2-position or a pharmaceutically acceptable salt thereof has a strong 11β-HSD1 inhibitory activity. Moreover, the triazole derivative of the invention exhibits an excellent blood-glucose level-lowering action and hence can be used for therapy of diabetes, insulin resistance.
TETRAHYDROCARBAZOLES AND DERIVATIVES
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Page/Page column 77, (2010/02/14)
The present invention relates to compounds of the formula (I) wherein R1, R2, R3, R4, R5, X1, X2, X3, X4, n, and k are defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for in the treatment and prophylaxis of diseases which are modulated by LXRα and/or LXR? agonists, including increased lipid and cholesterol levels, particularly low HDL-cholesterol, high LDL-cholesterol, atherosclerotic diseases, diabetes, particularly non-insulin dependent diabetes mellitus, metabolic syndrome, dyslipidemia, Alzheimer's disease, sepsis, inflammatory diseases such as colitis, pancreatitis, cholestasis/fibrosis of the liver, and diseases that have an inflammatory component such as Alzheimer's disease or impaired/improvable cognitive function.
Synthesis of thiadiazoles, triazoles and oxadiazoles from sulfonyl acetic acids via a common route
Padmavathi, Venkatapuram,Thriveni, Pinnu,Reddy, Boggu Jagan Mohan,Padmaja, Adivireddy
, p. 113 - 116 (2007/10/03)
A new class of five membered heterocycles, thiadiazoles, triazoles and oxadiazoles were prepared from sulfonyl acetic acids via acid hydrazides.
