3611-57-2

Basic information

• Product Name: 2-(4-methoxybenzyl)-benzo[b]thiophene
• Synonyms: 2-(4-methoxybenzyl)-benzo[b]thiophene
• CAS NO: 3611-57-2
• Molecular Weight: 254.353
• Mol File: 3611-57-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxybenzyl)-benzo[b]thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxybenzyl)-benzo[b]thiophene(3611-57-2)
• EPA Substance Registry System: 2-(4-methoxybenzyl)-benzo[b]thiophene(3611-57-2)

Safety Data

• Hazardous Substances Data: 3611-57-2(Hazardous Substances Data)

Upstream product

• 1195-14-8 2-Methylbenzothiophene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 4688-18-0 benzo[b]thiophen-2-ylmethyl acetate 
• 5720-07-0 4-methoxyphenylboronic acid 
• 17890-56-1 benzothiophene-2-methanol 
• 6314-28-9 benzo[b]thiophene-2-carboxylic acid 
• 104-21-2 p-methoxybenzyl acetate 
• 95-15-8 Benzo[b]thiophene 
• 184040-24-2 α-(2-benzo[b]thienyl)-4-methyoxybenzol alcohol 

Downstream Products

• 184040-27-5 2-(4-methoxybenzyl)-benzo[b]thiophene-3-sulfonyl chloride 

Relevant articles and documents

Synthesis of Indole/Benzofuran-Containing Diarylmethanes through Palladium-Catalyzed Reaction of Indolylmethyl or Benzofuranylmethyl Acetates with Boronic Acids

The palladium-catalyzed synthesis of indole/benzofurancontaining diarylmethanes starting from indolylmethyl or benzofuranylmethyl acetates with boronic acids has been investigated. The success of the reaction is influenced by the choice of precatalyst: with indolylmethyl acetates the reaction works well with [Pd(η3-C3H5)Cl]2/XPhos while with benzofuranylmethyl acetates Pd2(dba)3/XPhos is more efficient. The good to high yields and the simplicity of the experimental procedure make this protocol a versatile synthetic tool for the preparation of 2- and 3-substituted indoles and 2-benzo[b]furans. The methodology can be advantageously extended to the preparation of a key precursor of Zafirlukast.

Benzylic arylation of 2-methyl-5-membered heterocycles using TMP-bases

A new general Pd-catalyzed arylation of various 2-methyl-5-membered heterocycles is reported. This novel method requires Li-, Mg-, or Zn-TMP bases and allows selective metalation of the benzylic position. Subsequent Negishi cross-coupling provides the cor