361147-22-0

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 68, p. 3352, 2003 DOI: 10.1021/jo026864f

InChI:InChI=1/C11H8FN/c12-11-10(7-4-8-13-11)9-5-2-1-3-6-9/h1-8H

Upstream product

• 108-86-1 bromobenzene 
• 501435-91-2 5-bromo-2-fluoropyridin-3-ylboronic acid 
• 591-50-4 iodobenzene 
• 372-48-5 2-fluoropyridine 
• 36178-05-9 3-bromo-2-fluoropyridine 
• 98-80-6 phenylboronic acid 
• 766-11-0 5-bromo-2-fluoropyridine 

Downstream Products

• 847687-30-3 (2S)-2-{(S)-phenyl[(3-phenylpyridin-2-yl)thio]methyl}-4-(phenylmethyl)morpholine 

Relevant academic research and scientific papers

Continuous-Flow Synthesis of Biaryls by Negishi Cross-Coupling of Fluoro- and Trifluoromethyl-Substituted (Hetero)arenes

A continuous-flow method for the regioselective arylation of fluoroarenes and fluoropyridines has been developed. The telescoped procedure reported here consists of a three-step metalation, zincation, and Negishi cross-coupling sequence, providing efficient access to a variety of functionalized 2-fluorobiaryl products. Precise temperature control of the metalation step, made possible by continuous-flow technology, allowed for the efficient preparation of the arylated products in high yields and short residence times. Additionally, several examples of the regioselective arylation of benzotrifluoride derivatives are also provided.

PYRIDINYLMORPHOLINE DERIVATIVES

The invention relates to compounds of formula (I); wherein R, R1, R2 and X are as defined herein, their preparation and their use as pharmaceuticals.

TREATMENT OF PERVASIVE DEVELOPMENTAL DISORDERS WITH NOREPINEPHRINE REUPTAKE INHIBITORS

Provided are methods and medicaments for treating a Pervasive Developmental Disorder, comprising administering to a patient in need of such treatment an effective amount of a selective norepinephrine reuptake inhibitor.

TREATMENT OF HOT FLASHES, IMPULSE CONTROL DISORDERS AND PERSONALITY CHANGE DUE TO A GENERAL MEDICAL CONDITION

Selective norepinephrine reuptake inhibitors are useful for the prevention or treatment of hot flashes, vasomotor symptoms, impulse control disorders or personality change due to a general medical condition.

Versatile synthesis of 3,5-disubstituted 2-fluoropyridines and 2-pyridones

5-Bromo-2-fluoro-3-pyridylboronic acid (3) was prepared in high yield by ortho-lithiation of 5-bromo-2-fluoropyridine (1), followed by reaction with trimethylborate. Suzuki reaction of 3 with a range of aryl iodides gave 3-monosubstituted 5-bromo-2-fluoro