36178-05-9

Basic information

• Product Name: 3-Bromo-2-fluoropyridine
• Synonyms: 2-fluoro-3-bromopyridine;broMo-3 fluoro-2 pyridine;2--3-pyridyl broMidefluoride;2-fluoro -3-pyridyl broMide;3-BROMO-2-FLUOROPYRIDINE;3-Bromo-3-Fluoropyridine
• CAS NO: 36178-05-9
• Molecular Formula: C₅H₃BrFN
• Molecular Weight: 175.99
• EINECS: 1592732-453-0
• Product Categories: Fluorin-contained pyridine series;blocks;Bromides;FluoroCompounds;Pyridines;Pyridine;Pyridine series;Halides;Variety of halogenated heterocyclic series;Fluorine series
• Mol File: 36178-05-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 76°C
• Flash Point: 54℃
• Appearance: Light yellow liquid
• Density: 1.729
• Vapor Pressure: 2.55mmHg at 25°C
• Refractive Index: 1.5370-1.5410
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -2.79±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-2-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2-fluoropyridine(36178-05-9)
• EPA Substance Registry System: 3-Bromo-2-fluoropyridine(36178-05-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• RIDADR: 2810
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 36178-05-9(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow liquid

InChI:InChI=1/C6H6F4O2/c1-11-3-4(12-2)6(9,10)5(3,7)8/h1-2H3

Upstream product

• 372-48-5 2-fluoropyridine 
• 626-55-1 3-Bromopyridine 
• 75-05-8 acetonitrile 

Downstream Products

• 917969-51-8 4-bromo-2-fluoro-3-iodopyridine 
• 1876944-81-8 1-(3-bromopyridin-2-yl)cyclopropane-1-carbonitrile 
• 149490-03-9 8-chlorobenzo[b]pyrido[3,2-f ][1,4]oxazepin-5(6H)-one 
• 140413-11-2 9-methylpyrido<2,3-b><1,5>benzoxazepin-5(6H)-one 
• 244-93-9 Benzothieno<2,3-b>pyridine 
• 13534-99-1 2-Amino-3-bromopyridine 
• 84951-39-3 2-phenyl-4H-thiopyrano [2, 3-b] pyridin-4-one 

Relevant articles and documents

Carboxamidation of pyridines by the system of elemental fluorine- carbonitrile-water: A useful alternative to the chichibabin amination

The title reaction with pyridine, 4-methylpyridine, 3-methylpyridine, 3- bromopyridine, nicotinonitrile, and quinoline yields 2-carboxamido derivatives regioselectively. Isoquinoline is amidated at position 1.

Migration du lithium en serie pyridinique: double catalyse et reformage. Acces aux derives de la bromo-2 lithio-3 pyridine et des bromo-4 halogeno-2 lithio-3 pyridines

The lithium of an organolithium-pyridinic derivative can be moved from one position to an another by an intermolecular reaction.Two new reactions are possible for pyridinic organic synthesis: the isomerisation of any lithio derivative to a more stable one, and a reaction that transforms a mixture of various bromo-lithio derivatives into a single one.The processes involved and the experimental tools used are described in terms of the 2-bromo-3-lithio- and 4-bromo-2-halogeno-3-lithiopyridines derivatives synthesis.