361162-90-5Relevant articles and documents
PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS
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, (2012/02/01)
Compounds of the formula I or II: wherein X, m, Ar, R1 and R2 are as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.
Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epi
Wissner, Allan,Overbeek, Elsebe,Reich, Marvin F.,Floyd, M. Brawner,Johnson, Bernard D.,Mamuya, Nellie,Rosfjord, Edward C.,Discafani, Carolyn,Davis, Rachel,Shi, Xiaoqing,Rabindran, Sridhar K.,Gruber, Brian C.,Ye, Fei,Hallett, William A.,Nilakantan, Ramaswamy,Shen, Ru,Wang, Yu-Fen,Greenberger, Lee M.,Tsou, Hwei-Ru
, p. 49 - 63 (2007/10/03)
A series of of 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile derivatives that function as irreversible inhibitors of EGFR and HER-2 kinases have been prepared. These inhibitors have, at the 6-position, butynamide, crotonamide, and methacrylamide Mic