361189-64-2 Usage
Uses
Used in Bioconjugation:
PEG7-t-butyl ester is used as a crosslinker for bioconjugation, allowing the formation of covalent bonds between biomolecules and other molecules. The hydroxyl group enables further derivatization or replacement with other reactive functional groups, while the t-butyl protected carboxyl group can be deprotected under acidic conditions, facilitating the conjugation process.
Used in Chemical Biology and Medicinal Chemistry:
PEG7-t-butyl ester is used as a building block for the synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds in chemical biology and medicinal chemistry that require ligation. Its hydrophilic nature and functional groups make it a versatile component in the development of novel therapeutics and diagnostic tools.
Used in Drug Delivery Systems:
In the pharmaceutical industry, PEG7-t-butyl ester is used as a component in the design of drug delivery systems. Its hydrophilic PEG linker improves the solubility and stability of drug molecules, potentially enhancing their bioavailability and therapeutic efficacy.
Used in Targeted Protein Degradation:
PEG7-t-butyl ester can be synthetically incorporated into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC molecules) for targeted protein degradation. This application takes advantage of the molecule's ability to form stable bonds with specific target proteins, enabling the selective degradation of disease-causing proteins and offering a promising approach for the treatment of various diseases.
Used in the Synthesis of Conjugates:
PEG7-t-butyl ester is used as a key component in the synthesis of conjugates, which are hybrid molecules composed of two or more different molecules, such as drugs, peptides, or other biomolecules. The hydroxyl and t-butyl ester functional groups of PEG7-t-butyl ester facilitate the formation of these conjugates, potentially improving their pharmacological properties and targeting capabilities.
Check Digit Verification of cas no
The CAS Registry Mumber 361189-64-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,1,1,8 and 9 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 361189-64:
(8*3)+(7*6)+(6*1)+(5*1)+(4*8)+(3*9)+(2*6)+(1*4)=152
152 % 10 = 2
So 361189-64-2 is a valid CAS Registry Number.
361189-64-2Relevant academic research and scientific papers
Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof
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Page/Page column 207; 208; 209, (2019/11/11)
Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.
SPLICEOSTATIN ANALOGS
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Page/Page column 215-217, (2014/05/24)
The present invention is directed to novel cytotoxic spliceostatin analogs (I) and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
Synthesis and molecular recognition studies of the HNK-1 trisaccharide and related oligosaccharides. the specificity of monoclonal anti-HNK-1 antibodies as assessed by surface plasmon resonance and STD NMR
Tsvetkov, Yury E.,Burg-Roderfeld, Monika,Loers, Gabriele,Arda, Ana,Sukhova, Elena V.,Khatuntseva, Elena A.,Grachev, Alexey A.,Chizhov, Alexander O.,Siebert, Hans-Christian,Schachner, Melitta,Jimenez-Barbero, Jesus,Nifantiev, Nikolay E.
supporting information; experimental part, p. 426 - 435 (2012/03/11)
The human natural killer cell carbohydrate, HNK-1, plays function-conducive roles in peripheral nerve regeneration and synaptic plasticity. It is also the target of autoantibodies in polyneuropathies. It is thus important to synthesize structurally relate
