361198-68-7Relevant academic research and scientific papers
Synthesis and cytotoxicity of thieno[2,3-b]quinoline-2-carboxamide and cycloalkyl[b]thieno[3,2-e]pyridine-2-carboxamide derivatives
Leung, Euphemia,Pilkington, Lisa I.,van Rensburg, Michelle,Jeon, Chae Yeon,Song, Mirae,Arabshahi, Homayon J.,De Zoysa, Gayan Heruka,Sarojini, Vijayalekshmi,Denny, William A.,Reynisson, Jóhannes,Barker, David
, p. 1142 - 1154 (2019/05/24)
Seventy nine derivatives of thieno[2,3-b]quinolines, tetrahydrothieno[2,3-b]quinoline, dihydrocyclopenta[b]thieno[3,2-e]pyridine, cyclohepta[b]thieno[3,2-e]pyridine and hexahydrocycloocta[b]thieno[3,2-e]pyridine were either synthesized or obtained commercially and tested for their antiproliferative activity against HCT116, MDA-MB-468 and MDA-MB-231 human cancer cell lines. The most potent eight compounds were active against all cell lines with IC50 values in the 80–250 nM range. In general hexahydrocycloocta[b]thieno[3,2-e]pyridines were most active with increasing activity observed as larger cycloalkyl rings were fused to the pyridine ring.
A synthesis, in silico, in vitro and in vivo study of thieno[2,3-b]pyridine anticancer analogues
Arabshahi, Homayon J.,Van Rensburg, Michelle,Pilkington, Lisa I.,Jeon, Chae Yeon,Song, Mirae,Gridel, Ling-Mey,Leung, Euphemia,Barker, David,Vuica-Ross, Milena,Volcho, Konstantin P.,Zakharenko, Alexandra L.,Lavrik, Olga I.,Reynisson, Jóhannes
, p. 1987 - 1997 (2015/11/17)
The anticancer activity of the thieno[2,3-b]pyridines was explored by altering the ring size of the cyclo-aliphatic moiety. Five-, six-, seven- and eight-membered derivatives were tested against the NCI60 tumour cell panel. According to this assay the mos
Synthesis of some thienotetrahydroquinoline derivatives
Kamal El-Dean,Shaker,Abo El-Hassan,Abdel Latif
, p. 335 - 345 (2015/02/02)
2-Thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile (2) was easily S-alkylated to produce alkyl mercapto derivatives 3a-g. The latter compounds were cyclized to afford thienotetrahydroquinolines 4a-g. Several pyrimidothienotetrahydroquinolines 5a-d, and 6a-d were obtained from the condensation of compounds 4c-f with different reagents. o-Aminocarbohydrazide derivative 11 was reacted with aromatic aldehydes, acetylacetone, nitrous acid and CS2 to afford compounds 12-15. Compound 24 was coupled with aryldiazonium chloride to afford arylazo derivatives 25. Also it condensed with aromatic aldehydes to give arylidene derivatives 26. The latter compounds were reacted with malononitrile to give pyrano derivative 27.
Synthesis of some thienotetrahydroquinoline derivatives
Kamal El-Dean,Shaker,Abo El-Hassan,Abdel Latif
, p. 335 - 345 (2007/10/03)
2-Thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile (2) was easily S-alkylated to produce alkyl mercapto derivatives 3a-g. The latter compounds were cyclized to afford thienotetrahydroquinolines 4a-g. Several pyrimidothienotetrahydroquinolines 5a-d, and 6a-d were obtained from the condensation of compounds 4c-f with different reagents. o-Aminocarbohydrazide derivative 11 was reacted with aromatic aldehydes, acetylacetone, nitrous acid and CS2 to afford compounds 12-15. Compound 24 was coupled with aryldiazonium chloride to afford arylazo derivatives 25. Also it condensed with aromatic aldehydes to give arylidene derivatives 26. The latter compounds were reacted with malononitrile to give pyrano derivative 27.
