55735-44-9

Upstream product

• 108-94-1 cyclohexanone 
• 109-94-4 formic acid ethyl ester 
• 107-31-3 Methyl formate 

Downstream Products

• 65880-18-4 4,5,6,7-tetrahydro-1H-indole-2-carboxylic acid ethyl ester 
• 65880-17-3 ethyl 4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate 
• 134285-23-7 cyclohexane-1,2-dione p-vinylphenylhydrazone 
• 4241-13-8 2-oxo-1,2,5,6,7,8-hexahydro-3-quinoline-3-carbonitrile 
• 15839-18-6 2-methoxymethylenecyclohexanone 
• 23652-81-5 (Z)-2-((benzylamino)methylen)cyclohexanone 
• 112629-69-3 1,2,5,6,7,8-hexahydro-2-thioxoquinoline-3-carbonitrile 
• 329724-71-2 2-(3-cyano-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl)-N-(4-methoxy-phenyl)-acetamide 
• 332114-10-0 2-(3-cyano-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl)-N-p-tolyl-acetamide 
• 332114-09-7 2-(3-cyano-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl)-N-phenyl-acetamide 
• 314764-01-7 2-(3-cyano-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl)-acetamide 
• 310456-40-7 2-(2-oxo-2-phenyl-ethylsulfanyl)-5,6,7,8-tetrahydro-quinoline-3-carbonitrile 
• 780757-63-3 N'-benzylidene-3-amino-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbohydrazone 

Relevant academic research and scientific papers

A Method for the Preparation of β-Amino-α,β-unsaturated Carbonyl Compounds: Study of Solvent Effect and Mechanism

An efficient method for the preparation of β-amino-α,β-unsaturated carbonyl compounds is demonstrated. Bench-stable sodium 3-oxo-enolates were prepared from carbonyl compounds, and reacted with amines in the presence of an acid and a desiccant. DFT studie

Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

Zeste enhancer homolog 2 (EZH2) is highly expressed in various malignant tumors, which could silence tumor suppressor genes via trimethylation of H3K27. Herein was first reported a novel series of pyrrole-3-carboxamide derivatives carrying a pyridone fragment as EZH2 inhibitors. By combining computational modeling, in vitro cellular assays and further rational structure-activity relationship exploration and optimization, compound DM-01 showed powerful inhibition towards EZH2. DM-01 was found to have significant ability to reduce the cellular H3K27me3 level in K562 cells in the Western blot test. Meanwhile, our data showed that knockdown EZH2 in A549 cells resulted in a decrease of cell sensitivity to DM-01 at 50 and 100 μM. DM-01 could also increase the transcription expression of DIRAS3 in a dose-dependent manner, a tumor suppressor in the downstream of EZH2, suggesting it was worth investigating further as a lead compound.

Synthesis and cytotoxicity of thieno[2,3-b]quinoline-2-carboxamide and cycloalkyl[b]thieno[3,2-e]pyridine-2-carboxamide derivatives

Seventy nine derivatives of thieno[2,3-b]quinolines, tetrahydrothieno[2,3-b]quinoline, dihydrocyclopenta[b]thieno[3,2-e]pyridine, cyclohepta[b]thieno[3,2-e]pyridine and hexahydrocycloocta[b]thieno[3,2-e]pyridine were either synthesized or obtained commercially and tested for their antiproliferative activity against HCT116, MDA-MB-468 and MDA-MB-231 human cancer cell lines. The most potent eight compounds were active against all cell lines with IC50 values in the 80–250 nM range. In general hexahydrocycloocta[b]thieno[3,2-e]pyridines were most active with increasing activity observed as larger cycloalkyl rings were fused to the pyridine ring.

A synthesis, in silico, in vitro and in vivo study of thieno[2,3-b]pyridine anticancer analogues

The anticancer activity of the thieno[2,3-b]pyridines was explored by altering the ring size of the cyclo-aliphatic moiety. Five-, six-, seven- and eight-membered derivatives were tested against the NCI60 tumour cell panel. According to this assay the mos

AMIDE COMPOUNDS AND USE OF THE SAME

A renin inhibitor comprising a compound represented by the formula: wherein each symbol is as defined in the description, or a salt thereof or a prodrug thereof. The compound of the present invention has a superior renin inhibitory activity, and thus is useful as an agent for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like

NOVEL BENZYLAMINE DERIVATIVES AS CETP INHIBITORS

The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.

TRICYCLIC FUROPYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS

This invention relates to a compound of Formula (I) Wherein X is CH2, 0 or N(C1-C3)alkyl; Ar1 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents selected from (C1-C3)alkoxy, halo, OH, CF3, CN, NO2 and(C1-C3)alkyl, said alkyl being optionally substituted with CF3; or a pharmaceutically acceptable salt thereof, and its use in treating hyper-proliferative disorders.

A Convenient Synthesis of Nicotinate Esters from 3-Cyanopyridones

A convenient synthesis of alkyl-substituted ethyl nicotinates 8 was devised, using 3-cyano-2(1H)-pyridones 4.These were converted to the corresponding 2-bromo-3-cyanopyridines 5 with boiling phosphorus tribromide.The resulting 5 were smoothly debrominated