361212-70-6Relevant articles and documents
Wake-promoting agents: Search for next generation modafinil: Part IV
Louvet, Philippe,Schweizer, Dominique,Gourdel, Marie-Edith,Riguet, Eric,Yue, Christoph,Marcy, Val R.,Lin, Yin Guo,Gruner, John,Lesur, Brigitte,Bacon, Edward R.,Chatterjee, Sankar
scheme or table, p. 949 - 951 (2012/10/08)
In search of a next generation molecule to the novel wake promoting agent modafinil, a series of diphenyl ether derived wakefulness enhancing agents (in rat) was developed. From this work, racemic compound 16 was separated into its chiral enantiomers to p
Substituted (2-Phenoxyphenyl)acetic Acids with Antiinflammatory Activity. 1
Atkinson, David C.,Godfrey, Keith E.,Meek, Bernard,Saville, John F.,Stillings, Michael R.
, p. 1353 - 1360 (2007/10/02)
The synthesis and antiinflammatory activity of a series of substituted (2-phenoxyphenyl)acetic acids are described.Initial screening in the adjuvant arthritis test showed that halogen substitution in the phenoxy ring enhanced activity considerably.Ulcerogenic potential, as measured by the minimum ulcerogenic dose (MUD), was low in almost all the acids tested. acetic acid possessed the most favorable combination of potency with low toxicity, including ulcerogenicity, and this compound is now in therapeutic use.