[2-(2,4-Dichlorophenoxy)phenyl]methanol

Base Information

• Chemical Name: [2-(2,4-Dichlorophenoxy)phenyl]methanol
• CAS No.: 361212-70-6
• Molecular Formula: C13H10Cl2O2
• Molecular Weight: 269.127
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID60377083
• Wikidata: Q82166138
• Mol file: 361212-70-6.mol

Synonyms:[2-(2,4-dichlorophenoxy)phenyl]methanol;361212-70-6;(2-(2,4-Dichlorophenoxy)phenyl)methanol;1-[2-(2,4-dichlorophenoxy)phenyl]methanol;Oprea1_776172;SCHEMBL6961972;DTXSID60377083;DLYGGEPMVDZHRV-UHFFFAOYSA-N;MFCD01814784;2-(2,4-dichlorophenoxy)phenylmethanol;AKOS005070133;CS-0362775;2P-077;J-500511

Chemical Property of [2-(2,4-Dichlorophenoxy)phenyl]methanol

Chemical Property:

• Melting Point: 61-63°C
• PSA: 29.46000
• LogP: 4.27800
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 268.0057849
• Heavy Atom Count: 17
• Complexity: 238

Purity/Quality:

99% ^*data from raw suppliers

[2-(2,4-Dichlorophenoxy)phenyl]methanol >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CO)OC2=C(C=C(C=C2)Cl)Cl

Technology Process of [2-(2,4-Dichlorophenoxy)phenyl]methanol

There total 9 articles about [2-(2,4-Dichlorophenoxy)phenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium hydrogen sulfate (7681-38-1) + 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran (96042-30-7) + 2-(2,4-dichlorophenoxy)benzaldehyde (86309-06-0) → 1-[2-(2,4-dichlorophenoxy)phenyl]methanol (361212-70-6)

Guidance literature:

With sodium borohydrid; sodium hydrogencarbonate; In n-heptane; ethyl acetate; isopropyl alcohol;

Reference yield:

2-(2,4-dichlorophenoxy)benzaldehyde (86309-06-0) → 1-[2-(2,4-dichlorophenoxy)phenyl]methanol (361212-70-6)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 16h; Ambient temperature;

DOI:10.1021/jm00364a004

Reference yield:

potassium 2-formylphenolate (33838-32-3) → 1-[2-(2,4-dichlorophenoxy)phenyl]methanol (361212-70-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 2 h / 220 °C

2: sodium borohydride / ethanol / 16 h / Ambient temperature

With sodium tetrahydroborate; In ethanol;

DOI:10.1021/jm00364a004

upstream raw materials:

2-(2,4-dichlorophenoxy)benzaldehyde

potassium 2-formylphenolate

sodium 2,4-dichlorophenolate

ortho-bromobenzaldehyde

Downstream raw materials:

fenclofenac

2-<2-(2,4-dichlorophenoxy)phenyl>ethanol

<2-(2,4-dichlorophenoxy)phenyl>acetyl chloride

3-<2-(2,4-dichlorophenoxy)phenyl>propionic acid