36155-35-8

Usage

Uses

Used in Pharmaceutical Research:
2-[(4-Chlorophenyl)thio]ethanamine is used as a research chemical for studying the effects of amphetamine derivatives on the central nervous system. Its ability to increase the levels of neurotransmitters such as dopamine, norepinephrine, and serotonin makes it a valuable tool for understanding the mechanisms of action of stimulant and hallucinogenic substances.
Used in Toxicological Studies:
Due to its neurotoxicity and association with several deaths and hospitalizations, 2-[(4-Chlorophenyl)thio]ethanamine is used in toxicological studies to investigate the harmful effects of synthetic amphetamines on human health. These studies aim to develop better understanding of the risks associated with the use of such substances and to inform regulatory policies and public health interventions.

InChI:InChI=1/C8H10ClNS/c9-7-1-3-8(4-2-7)11-6-5-10/h1-4H,5-6,10H2

Upstream product

• 151-56-4 ethyleneimine 
• 106-54-7 p-Chlorothiophenol 
• 2576-47-8 2-bromoethylamine hydrobromide 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 497-25-6 dimethylenecyclourethane 

Downstream Products

• 112626-21-8 N-[2-(4-chloro-phenylsulfanyl)-ethyl]-N'-diethoxyphosphoryl-thiourea 
• 100380-13-0 3-methyl-crotonic acid-[2-(4-chloro-phenylsulfanyl)-ethylamide] 
• 53492-49-2 3-[2-(4-chloro-phenylsulfanyl)-ethyl]-sydnone 
• 133760-86-8 2-[2-(4-Chloro-phenylsulfanyl)-ethylamino]-1-phenyl-ethanol 
• 361145-75-7 3-(1H-1,2,3-benzotriazol-1-yl)-2-{2-[(4-chlorophenyl)thio]ethyl}-1-isoindolinone 
• 913818-13-0 [FeCl₂((CH₃)2C₆H₃NC₁₂H₆NCH₂CH₂SC₆H₄Cl)]2 
• 945653-12-3 [CoCl₂((CH(CH₃)2)2C₆H₃NC₁₂H₆NCH₂CH₂SC₆H₄Cl)]2 
• 1382488-82-5 N-(2-((4-chlorophenyl)thio)ethyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)sulfonyl)propanamide 

Relevant academic research and scientific papers

Synthesis and Antichlamydial Activity of Molecules Based on Dysregulators of Cylindrical Proteases

Chlamydia trachomatis is the most common sexually transmitted bacterial disease globally and the leading cause of infertility and preventable infectious blindness (trachoma) in the world. Unfortunately, there is no FDA-approved treatment specific for chlamydial infections. We recently reported two sulfonylpyridines that halt the growth of the pathogen. Herein, we present a SAR of the sulfonylpyridine molecule by introducing substituents on the aromatic regions. Biological evaluation studies showed that several analogues can impair the growth of C. trachomatis without affecting host cell viability. The compounds did not kill other bacteria, indicating selectivity for Chlamydia. The compounds presented mild toxicity toward mammalian cell lines. The compounds were found to be nonmutagenic in a Drosophila melanogaster assay and exhibited a promising stability in both plasma and gastric fluid. The presented results indicate this scaffold is a promising starting point for the development of selective antichlamydial drugs.

Alternatives to pyridinediimine ligands: Syntheses and structures of metal complexes supported by donor-modified α-diimine ligands

This report describes the synthesis and characterization of metal halide complexes (M = Mn, Fe, Co) supported by a new family of pendant donor-modified α-diimine ligands. The donor (N, O, P, S) substituent is linked to the α-diimine by a short hydrocarbon

N-acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.

N-Acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula Are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.