361568-82-3

Upstream product

• 123-75-1 pyrrolidine 
• 361568-78-7 (-)-tert-butyl (S)-3-acetyl-4-benzylpiperazine-1-carboxylate 

Downstream Products

• 361568-90-3 (-)-tert-butyl (S)-4-[2-(3,4-dichlorophenyl)acetyl]-3-[(R)-1-(pyrrolidin-1-yl)ethyl]piperazine-1-carboxylate 

Relevant academic research and scientific papers

Methylated analogues of methyl (R)-4-(3,4-dichlorophenylacetyl)-3-(pyrrolidin-1-ylmethyl) piperazine-1-carboxylate (GR-89,696) as highly potent κ-receptor agonists: Stereoselective synthesis, opioid-receptor affinity, receptor selectivity, and functional

Analogues of the κ-receptor agonist methyl (R)-4-(3,4-dichlorophenylacetyl)-3-(pyrrolidin-1-ylmethyl) piperazine-1-carboxylate (GR-89,696, 6) bearing an additional methyl substituent in the side chain are synthesized and evaluated for their κ-receptor aff

Synthesis and stereoselective κ-receptor binding of methylated analogues of GR-89.696

Stereoselective synthesis of all four stereoisomers of methylated analogues 8 of the κ-receptor agonist GR-89.696 is presented. Starting with orthogonally protected piperazine derivatives (R,R)-4 and (S,S)-4, the reaction sequence involves oxidation, redu