3617-20-7

Basic information

• Product Name: 3(2H)-Pyridazinone, 4,5-dihydro-2-methyl-6-phenyl-
• Synonyms: 3(2H)-Pyridazinone, 4,5-dihydro-2-methyl-6-phenyl-
• CAS NO: 3617-20-7
• Molecular Formula: C11H12N2O
• Molecular Weight: 188.229
• Mol File: 3617-20-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3(2H)-Pyridazinone, 4,5-dihydro-2-methyl-6-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Pyridazinone, 4,5-dihydro-2-methyl-6-phenyl-(3617-20-7)
• EPA Substance Registry System: 3(2H)-Pyridazinone, 4,5-dihydro-2-methyl-6-phenyl-(3617-20-7)

Safety Data

• Hazardous Substances Data: 3617-20-7(Hazardous Substances Data)

Upstream product

• 74-83-9 methyl bromide 
• 1011-46-7 6-phenyl-2,3,4,5-tetrahydropyridazin-3-one 
• 71-43-2 benzene 
• 1444833-42-4 C₁₁H₁₁BrN₂O 
• 1444833-13-9 C₁₁H₁₀Cl₂N₂O 
• 1444832-64-7 C₁₁H₁₁ClN₂O 
• 2051-95-8 succinylbenzene 
• 1028250-15-8 C₁₁H₁₄N₂O₂ 
• 2165-04-0 2-methyl-6-phenylpyridazin-3(2H)-one 

Downstream Products

• 76617-91-9 2-Methyl-3,3,6,6-tetraphenylhexahydropyridazine 
• 2165-04-0 2-methyl-6-phenylpyridazin-3(2H)-one 

Relevant articles and documents

Brine Shrimp (Artemia salina) Lethality Bioassay of Some 2-(Alkyl/Aryl)-6-Phenyl-4,5-Dihydropyridazin-3(2H)-one Derivatives

A series of pyridazinone derivatives, 2-(alkyl/aryl)-6-phenyl-4,5-dihydropyridazin-3(2H)-ones (3a-h), was synthesized from 6-phenyl-4,5-dihydropyridazin-3(2H)-one (2). Compound 2 was synthesized from benzoylpropionic acid (1). The synthesized compounds were characterized on the basis of their spectral (infrared, proton nuclear magnetic resonance, carbon-13 nuclear magnetic resonance, and mass spectra) and elemental analytical data. The compounds 2 and 3a-h and potassium dichromate (as reference drug) were tested at the dose level of 10, 20, and 30 μg/mL. Compounds 3d and 3b exhibited potent brine shrimp lethality with LC50values of 4.023 μg and 4.20 μg. Other compounds 3g, 3f, 3c, 3h, 2, 3a, and 3e also showed significant cytotoxic activity with LC50values of 13.91, 12.58, 11.91, 11.76, 10.58, 9.76, and 7.46 μg, respectively. The present study supports that brine shrimp bioassay is a simple, reliable, and suitable method for estimation of bioactivity of synthesized compounds and provides support for their use in medicine.

A simple and efficient synthesis of 4-mercapto-6-phenylpyridazin-3(2h)-ones

A simple and efficient synthesis of the novel 4-mercapto-6-phenylpyridazin- 3(2H)-ones from the reaction of 6-phenyl-4,5-dihydropyridazin-3(2H)-ones with excess thionyl chloride under mild conditions, is described.

Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents

Substituted 6-phenyl-3(2H)-pyridazinone compounds are useful as cardiotonic agents. Said compounds cause a significant increase in myocardial contractility in the anesthetized dog. Said compounds are produced by reacting substituted γ-oxobenzenebutanoic acids with suitably substituted hydrazines to provide 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are dehydrogenated to the desired product. The intermediate 6-phenyl-4,5-dihydro-3(2H)-pyridazinones are themselves useful as cardiotonic agents.