3618-11-9Relevant academic research and scientific papers
Synthesis of trans -Cycloalkenes via Enantioselective Cyclopropanation and Skeletal Rearrangement
Miura, Tomoya,Nakamuro, Takayuki,Liang, Chia-Jung,Murakami, Masahiro
, p. 15905 - 15908 (2015/02/19)
An efficient one-pot two-step procedure for asymmetric synthesis of piperidine-fused trans-cycloalkenes is reported. The method comprises the initial enantioselective installation of another cyclopropane ring onto methylenecyclopropanes and the subsequent thermal skeletal rearrangement in which the installed and inherent cyclopropane rings are both opened. A concerted mechanism is proposed for the latter thermal rearrangement reaction together with a closed transition state model.
Hydroindation of allenes and its application to radical cyclization
Hayashi, Naoki,Hirokawa, Yusuke,Shibata, Ikuya,Yasuda, Makoto,Baba, Akio
supporting information; experimental part, p. 1949 - 1954 (2009/01/31)
Hydroindation of allenes and radical cyclization of 1,2,7-trienes (allenenes) were accomplished by HInCl2 with high regioselectivity to afford a variety of cyclic compounds. The resulting vinylic indiums could be used for successive coupling reactions in a one-pot procedure. The use of HInCl2 generated slowly in situ is extremely effective for the radical cyclization. The Royal Society of Chemistry.
