36187-69-6

Basic information

• Product Name: Ethyl 4-bromo-3-oxopentanoate
• Synonyms: Ethyl 4-bromo-3-oxopentanoate
• CAS NO: 36187-69-6
• Molecular Formula: C₇H₁₁BrO₃
• Molecular Weight: 223.06444
• Mol File: 36187-69-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 242.64 °C at 760 mmHg
• Flash Point: 100.545 °C
• Appearance: /
• Density: 1.41 g/cm³
• Vapor Pressure: 0.034mmHg at 25°C
• Refractive Index: 1.468
• PKA: 9.45±0.50(Predicted)
• CAS DataBase Reference: Ethyl 4-bromo-3-oxopentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-bromo-3-oxopentanoate(36187-69-6)
• EPA Substance Registry System: Ethyl 4-bromo-3-oxopentanoate(36187-69-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 36187-69-6(Hazardous Substances Data)

Usage

General Description

Ethyl 4-bromo-3-oxopentanoate, also known as ethyl bromo malonate, is an organic compound with the molecular formula C7H11BrO3. It is a colorless liquid with a slightly fruity odor and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Ethyl 4-bromo-3-oxopentanoate is also used as a building block in the preparation of various organic compounds, including esters and carboxylic acids. Additionally, it can be utilized in the production of perfumes and flavoring agents. Due to its structural properties, it is considered to be a versatile and valuable chemical in the field of organic synthesis.

InChI:InChI=1/C7H11BrO3/c1-3-11-7(10)4-6(9)5(2)8/h5H,3-4H2,1-2H3

Upstream product

• 141-78-6 ethyl acetate 
• 7148-74-5 2-Bromopropionyl chloride 
• 4111-54-0 lithium diisopropyl amide 
• 4949-44-4 ethyl propanoylacetate 

Downstream Products

• 679834-85-6 ethyl [2-(3-iodophenyl)-5-methyl-1,3-oxazol-4-yl]acetate 
• 859521-92-9 2-(2-amino-5-methylthiazol-4-yl)acetic acid ethyl ester 
• 175136-30-8 2-[5-methyl-2-phenyl-1,3-thiazol-4-yl]ethanol 
• 6179-14-2 2,5-dimethylbenzo[b]thiophene-3-acetic acid 
• 36904-76-4 (±)-4-hydroxy-5-methylfuran-2(5H)-one 
• 866534-33-0 [5-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-4-yl]-acetic acid ethyl ester 
• 115320-89-3 4,5-dihydro-5-methyl-4-oxo-2-(phenylamino)-3-furancarboxylic acid 
• 679834-90-3 (2S)-2-[(2-benzoylphenyl)amino]-3-(4-{2-[2-(3-{3-[(tert-butoxycarbonyl)amino]-1-propynyl}phenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy}phenyl)propanoic acid 
• 679834-89-0 methyl (2S)-2-[(2-benzoylphenyl)amino]-3-(4-{2-[2-(3-{3-[(tert-butoxycarbonyl)amino]-1-propynyl}phenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy}phenyl)propanoate 
• 679834-87-8 methyl (2S)-2-[(2-benzoylphenyl)amino]-3-(4-{2-[2-(3-iodophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy}phenyl)propanoate 
• 679834-86-7 2-[2-(3-iodophenyl)-5-methyl-1,3-oxazol-4-yl]ethanol 
• 115320-88-2 ethyl 4,5-dihydro-5-methyl-4-oxo-2-(phenylamino)-3-furancarboxylate 

Relevant articles and documents

β-LACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS

Provided are β-lactam compounds of formula (I), their preparation and use as antibiotic agents for the treatment of bacterial infections: Wherein X, W, R 1, R 2 and R 3 are defined herein.

Cephalosporin drug intermediate and synthesis method thereof

The invention provides a cephalosporin drug intermediate and a synthesis method thereof, and belongs to the technical field of medicine synthesis. The synthesis method comprises the following steps: d) reacting a compound with a structure as shown in a formula (IV) with stannic oxide to obtain a compound with a structure as shown in a formula (V-1); and e) reacting the compound with the structureas shown in the formula (V-1) with sodium hydroxide to obtain a compound with a structure as shown in a formula (V-2); and according to the synthetic method of the cephalosporin drug intermediate provided by the invention, the obtained cephalosporin drug intermediate can be used as a cephalosporin antibiotic intermediate for preparing cephalosporin antibiotics. The method has the advantages of wide raw material sources, reasonable reaction route, mild reaction conditions and high product yield, and is suitable for large-scale production.

SHMT INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.