3620-16-4

Upstream product

• 680-42-2 diethyl 2-fluoro-2-nitromalonate 
• 626-35-7 nitroacetic acid ethyl ester 
• 64-17-5 ethanol 
• 131153-10-1 trans-1,2-difluorodinitroethylene 
• 815-61-2 Fluor-nitro-essigsaeure-chlorid 

Downstream Products

• 100366-14-1 ethyl fluoronitro(phenylthio)acetate 
• 1262896-35-4 (2R,3R)-ethyl 3-(4-chlorophenyl)-2-fluoro-2-nitro-5-oxohexanoate 
• 1262896-23-0 (2S,3R)-ethyl 3-(4-chlorophenyl)-2-fluoro-2-nitro-5-oxohexanoate 
• 1262896-39-8 (2R,3R)-ethyl 2-fluoro-2-nitro-3-(4-nitrophenyl)-5-oxohexanoate 
• 1262896-27-4 (2S,3R)-ethyl 2-fluoro-2-nitro-3-(4-nitrophenyl)-5-oxohexanoate 
• 1262896-45-6 (2R,3R)-ethyl 2-fluoro-2-nitro-2-(3-oxocyclohexyl)acetate 
• 1262896-33-2 (2S,3R)-ethyl 2-fluoro-2-nitro-2-(3-oxocyclohexyl)acetate 
• 1262896-38-7 (2R,3R)-ethyl 2-fluoro-3-(4-methoxyphenyl)-2-nitro-5-oxohexanoate 
• 1262896-26-3 (2S,3R)-ethyl 2-fluoro-3-(4-methoxyphenyl)-2-nitro-5-oxohexanoate 
• 1262896-34-3 (2R,3R)-ethyl 2-fluoro-3-(4-fluorophenyl)-2-nitro-5-oxohexanoate 
• 1262896-22-9 (2S,3R)-ethyl 2-fluoro-3-(4-fluorophenyl)-2-nitro-5-oxohexanoate 
• 1262896-37-6 (2R,3R)-ethyl 2-fluoro-2-nitro-5-oxo-3-p-tolylhexanoate 
• 1262896-25-2 (2S,3R)-ethyl 2-fluoro-2-nitro-5-oxo-3-p-tolylhexanoate 
• 1262896-41-2 (2R,3R)-ethyl 3-(3-chlorophenyl)-2-fluoro-2-nitro-5-oxohexanoate 

Relevant academic research and scientific papers

Synthesis and Properties of 1,2-Difluorodinitroethylene

1,2-Difluorodinitroethylene was synthesized by flash vacuum pyrolysis of 1,2-difluorotetranitroethane.X-ray crystallography showed that one of the two nitro groups is out of the plane of the rest of the molecule and that the C-C double-bond distance is unusually short at 1.284 Angstroem. 1,2-Difluorotetranitroethane reacted with alcohols to give alkyl fluoronitroacetates and with anthracene and cyclopentadiene to give Diels-Alder adducts.

Fluorination and chlorination of nitroalkyl groups

Heterocycles substituted with a nitromethyl (CH2NO2) or phenyl-nitromethyl (CHPhNO2) group were prepared by reaction of a methyl- or phenylmethyl-substituted heterocycle, respectively, with lithium di-isopropylamide follow

Catalyzed fluorination of carbonyl compounds

The present invention provides a method of substituting a carbonyl compound with fluorine at the α-position, comprising reaching the carbonyl compound with a fluorinating present of a metal-containing catalyst. The reaction results in replacement of a hydrogen atom by fluorine. The catalyst, which is used in a catalytically effective amount, is preferably a transition metal. In one class of methods the catalyst is a transition metal compound. In another class of methods, the catalyst is an elemental metal, in which case the carbonyl compound has an activating group attached to the carbon atom which is substituted by fluorine.

Elemental fluorine. Part 9 : Catalysis of the direct fluorination of 2-substituted carbonyl compounds

Catalysis of the reaction between fluorine and a range of 2-substituted carbonyl compounds has been investigated. Most notably, the preparation of diethyl-2-fluoromalonate has been achieved in high yield by fluorination of diethylmalonate in the presence of hydrated copper nitrate. Reactions between fluorine and carbanions derived from 2-substituted carbonyl compounds, including phosphonates, sulphones and nitriles, are also discussed.