362047-05-0Relevant academic research and scientific papers
Synthesis, Structure, and Optical Properties of Di-m-benzihexaphyrins (1.1.0.0.0.0) and Di-m-benziheptaphyrins (1.0.1.0.0.0.0): Blackening of m-Phenylene-Linked Dicarbaporphyrinoids by Simple ?-Expansion
Sulfikarali, Thondikkal,Ajay, Jayaprakash,Suresh, Cherumuttathu H.,Bijina, Padinjare V.,Gokulnath, Sabapathi
, p. 8021 - 8028 (2020)
Acid-catalyzed condensation of a newly prepared di-m-benzipentapyrrane with appropriate mono- A nd diheterocyclic dialcohols selectively produced stable di-m-benzihexaphyrins and di-m-benziheptaphyrins with only two meso-carbon bridges. Single-crystal X-ray diffraction analyses reveal planar conformation with slight distortion of bridged phenylene rings. Despite the presence of m-phenylene units interrupting the global delocalization, the presence of bithiophene units in di-m-benziheptaphyrins 3a-b exhibits altered optical features covering the entire visible region (ca. 250-720 nm), exhibiting a black dye property as a metal-free porphyrinoid.
Inhibition of the HIV-1 Rev-RRE complex formation by unfused aromatic cations
Xiao, Ge,Kumar, Arvind,Li, Ke,Rigl, C. Ted,Bajic, Miroslav,Davis, Tina M.,Boykin, David W.,Wilson, W. David
, p. 1097 - 1113 (2007/10/03)
RNA viruses cause a wide range of human diseases. Development of new agents to target such viruses is an active area of research. Towards this goal, a series of diphenylfuran cations as potential inhibitors of the Rev-RRE complex have been designed and synthesized. Analysis of the interaction of the diphenylfurans with RRE and TAR RNA model systems by gel shift assays indicates that they exhibit both sequence and structure-dependent binding modes. Our results show a strong interaction between the diphenylfuran ring system and RRE bases, while the TAR interactions are much weaker with the compounds that are the best inhibitors of Rev-RRE.
