362047-03-8Relevant academic research and scientific papers
Discovery of new G-quadruplex binding chemotypes
Ohnmacht, Stephan A.,Varavipour, Ehsan,Nanjunda, Rupesh,Pazitna, Ingrida,Di Vita, Gloria,Gunaratnam, Mekala,Kumar, Arvind,Ismail, Mohamed A.,Boykin, David W.,Wilson, W. David,Neidle, Stephen
supporting information, p. 960 - 963 (2014/01/06)
We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent
Visible-light-induced Ci-S bond activation: Facile access to 1,4-diketones from β-ketosulfones
Xuan, Jun,Feng, Zhu-Jia,Chen, Jia-Rong,Lu, Liang-Qiu,Xiao, Wen-Jing
supporting information, p. 3045 - 3049 (2014/03/21)
A novel method for the synthesis of 1,4-diketones from β-ketosulfones was developed by means of a visible light-induced Ci￡S bond activation process. Symmetrical and unsymmetrical 1,4-diketones can be easily prepared in moderate to good yields. A new and efficient method for the synthesis of 1,4-diketones from β-ketosulfones was developed by means of a visible-light-induced Ci￡S bond activation process (see scheme). Symmetrical and unsymmetrical 1,4-diketones can be easily prepared in moderate to good yields.
Structural selectivity of aromatic diamidines
Chaires, Jonathan B.,Ren, Jinsong,Hamelberg, Donald,Kumar, Arvind,Pandya, Vandna,Boykin, David W.,Wilson, W. David
, p. 5729 - 5742 (2007/10/03)
Competition dialysis was used to study the interactions of 13 substituted aromatic diamidine compounds with 13 nucleic acid structures and sequences. The results show a striking selectivity of these compounds for the triplex structure poly dA:(poly dT)su
One-step preparation of symmetrical 1,4-diketones from α-halo ketones in the presence of Zn-I2 as a condensation agent
Ceylan, Mustafa,Guerdere, M. Burcu,Budak, Yakup,Kazaz, Cavit,Secen, Hasan
, p. 1750 - 1754 (2007/10/03)
Eleven 1,4-diphenylbutane-1,4-diones have been prepared in one step from the corresponding α-halo acetophenones under the action of Zn-I 2 as a condensation agent with moderate to high yields. The mechanistic pathway of the reaction can be explained by the Wurtz-like self-condensation of α-halo ketones. Similarly, 3-chloropentane-2,4-dione gave 3,4-diacetylhexane-2,5-dione, a Wurtz-like condensation product.
Inhibition of the HIV-1 Rev-RRE complex formation by unfused aromatic cations
Xiao, Ge,Kumar, Arvind,Li, Ke,Rigl, C. Ted,Bajic, Miroslav,Davis, Tina M.,Boykin, David W.,Wilson, W. David
, p. 1097 - 1113 (2007/10/03)
RNA viruses cause a wide range of human diseases. Development of new agents to target such viruses is an active area of research. Towards this goal, a series of diphenylfuran cations as potential inhibitors of the Rev-RRE complex have been designed and synthesized. Analysis of the interaction of the diphenylfurans with RRE and TAR RNA model systems by gel shift assays indicates that they exhibit both sequence and structure-dependent binding modes. Our results show a strong interaction between the diphenylfuran ring system and RRE bases, while the TAR interactions are much weaker with the compounds that are the best inhibitors of Rev-RRE.
