362047-12-9

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 591-18-4 1-Bromo-3-iodobenzene 
• 3989-13-7 2-(3-bromophenyl)ethynyltrimethylsilane 
• 362047-03-8 1,4-bis(3-bromophenyl)butane-1,4-dione 

Downstream Products

• 186391-33-3 2,5-bis-(3-cyanophenyl) thiophene 
• 186391-35-5 C₂₂H₂₂N₂O₂S 

Relevant academic research and scientific papers

A saddle-shaped macrocycle comprising 2,5-diphenylthiophene units

2,5-Diphenylthiophene-based macrocycles were synthesized by Ni-mediated coupling of the corresponding building units. X-ray analysis revealed that the cyclic trimer had a saddle-shaped structure due to the steric demands of the biphenyl and thiophene-phen

Pseudo five-component synthesis of 2,5-di(hetero)arylthiophenes via a one-pot Sonogashira-Glaser cyclization sequence

Based upon a consecutive one-pot Sonogashira-Glaser coupling-cyclization sequence a variety of 2,5-di(hetero)arylthiophenes were synthesized in moderate to good yields. A single Pd/Cu-catalyst system, without further catalyst addition, and easily available, stable starting materials were used, resulting in a concise and highly efficient route for the synthesis of the title compounds. This novel pseudo five-component synthesis starting from iodo(hetero)arenes is particularly suitable as a direct access to well-defined thiophene oligomers, which are of peculiar interest in materials science.

Inhibition of the HIV-1 Rev-RRE complex formation by unfused aromatic cations

RNA viruses cause a wide range of human diseases. Development of new agents to target such viruses is an active area of research. Towards this goal, a series of diphenylfuran cations as potential inhibitors of the Rev-RRE complex have been designed and synthesized. Analysis of the interaction of the diphenylfurans with RRE and TAR RNA model systems by gel shift assays indicates that they exhibit both sequence and structure-dependent binding modes. Our results show a strong interaction between the diphenylfuran ring system and RRE bases, while the TAR interactions are much weaker with the compounds that are the best inhibitors of Rev-RRE.