36207-43-9 Usage
General Description
DL-Methionine hydroxamate is a type of amino acid hydroxamate, which are derivatives of amino acids. Hydroxamates are best known for their biological and medicinal applications, particularly as inhibitors for various enzymes. DL-Methionine hydroxamate particularly consists of methionine, an essential amino acid required for protein synthesis and growth in humans, and hydroxamate, a common moiety in medicinal chemistry identified as a potent chelator of metal ions. Because of these properties, this chemical compound may have potential uses in pharmaceuticals, medical research, and biotechnology. However, like other hydroxamates, toxicity and adverse effects are a concern and need to be studied extensively.
Check Digit Verification of cas no
The CAS Registry Mumber 36207-43-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,2,0 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 36207-43:
(7*3)+(6*6)+(5*2)+(4*0)+(3*7)+(2*4)+(1*3)=99
99 % 10 = 9
So 36207-43-9 is a valid CAS Registry Number.
36207-43-9Relevant articles and documents
Methionine analogues as inhibitors of methionyl-tRNA synthetase
Lee, Jeewoo,Kang, Mee Kyoung,Chun, Moon Woo,Jo, Yeong Joon,Kwak, Jin Hwan,Kim, Sunghoon
, p. 3511 - 3514 (2007/10/03)
A series of methionine analogues have been synthesized as inhibitors of methionyl-tRNA synthetase and evaluated for their inhibitory activities of E. coli methionyl-tRNA synthetase and bacterial growth. Among them, L-methionine hydroxamate 20 has proved to be the best inhibitor of the enzyme with K(i) = 19 μM and showed a growth inhibition against E. coli JM 109, P. vulganis 6059 and C. freundii 8090.
