452-95-9Relevant academic research and scientific papers
Palladium-Catalyzed Allylic Alkylation of Aldimine Esters with Vinyl-Cyclopropanes to Yield α,α-Disubstituted α-Amino Acid Derivatives
Wang, Jiahua,Dai, Zonghao,Xiong, Cheng,Zhu, Jin,Lu, Jinrong,Zhou, Qingfa
supporting information, p. 5105 - 5111 (2019/11/11)
A synthetically useful approach for the synthesis of functionalized α, α-disubstituted α-amino acid derivatives via palladium-catalyzed 1,7 addition of readily available aldimine esters to vinylcyclopropanes is reported. This methodology was operated under mild conditions, affording α-allylic α-amino esters in good to excellent yields and excellent regio- and stereoselectivity. This transformation displays broad functional-group tolerance and enantioselective allylic alkylation has also been realized using a chiral phosphine ligand to provide the desired product. (Figure presented.).
Solid phase preparation of amines
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, (2008/06/13)
A method for the solid phase preparation of an amine by a novel synthesis is described where a diol is monoalkylated with a chloromethyl resin followed by reaction with N,N'-carbonyldimidazole to afford a resin-bound tertiary-alkoxycarbonyl-imidazole which is subsequently N-alkylated and then sequentially treated with appropriate building blocks and reagents to afford a resin-bound amine which affords the desired amine after treatment with an acid as well as other valuable intermediates used in the process.
Synthesis and binding affinities of novel spirocyclic lactam peptidomimetics of somatostatin
Damour, Dominique,Barreau, Michel,Blanchard, Jean-Charles,Burgevin, Marie-Claude,Doble, Adam,Pantel, Guy,Labaudiniere, Richard,Mignani, Serge
, p. 943 - 944 (2007/10/03)
Synthesis of novel spirocyclic lactam peptidomimetics of the binding domain of somatostatin from commercially available D, L-methionine is described.
